생명과학회지 (Journal of Life Science)

  • 제19권1호
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  • Pages.147-151
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  • 2009
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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건강기능성 식품소재로서 pinitol의 특성

Characteristics of Pinitol as a Functional Food Biomaterial

  • 손민식 (경북대학교 생명식품공학부 및 대학원 나노과학기술과) ;
  • 서명선 (송광매원) ;
  • 이상한 (경북대학교 생명식품공학부 및 대학원 나노과학기술과)
  • Son, Min-Sik (Devision of Life and Food Science, and Nano-science and Technology, Graduate School, Kyungpook National University) ;
  • Seo, Myung-Seon (SongKwangMaeWon Company, Ltd.) ;
  • Lee, Sang-Han (Devision of Life and Food Science, and Nano-science and Technology, Graduate School, Kyungpook National University)
  • 발행 : 2009.01.30
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초록

D-pinitol, another chemical structure of 3-O-methyl-D-chiro-inositol, is an important insulin-sensitizer. The purpose of this review is to examine the characteristics of pinitol and other analogs as functional food biomaterials which were well known to reduce blood glucose levels. Pinitol can be converted to chiro-inositol in normal humans, while diabetic patients can not use the molecule, resulting in exhibiting low level of chiro-inositol in their urine. Recently, it is reported that pinitol can trigger phospholipase C/D, thus the rate of glucose metabolism accelerates to use as fuel for human body. To not only reduce insulin resistance of diabetic patients, but also alleviate the symptoms of diabetes, obesity, and muscle contraction, pinitol and its dietary supplementation is needed.

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참고문헌

  1. Asplin, I., G. Galasko and J. Larner. 1993. Chiro-inositol deficiency and insulin resistance: A comparison of the chiroinositol and myo-inositon containing insulin mediators isolated from urine, hemo- dialysate, and muscle of control and type II diabetic subjects. Proc. Natl. Acad. Sci. USA 90, 5924-5928 https://doi.org/10.1073/pnas.90.13.5924
  2. Bates, S. H., R. B. Jones and C. J. Bailey. 2000. Insulin-like effect of pinitol. Br. J. Pharmacol. 130, 1944-1948 https://doi.org/10.1038/sj.bjp.0703523
  3. Buford, T. W., R. B. Kreider, J. R. Stout, M. Greenwood, B. Campbell, M. Spano, T. Ziegenfuss, H. Lopez, J. Landis and J. Antonio. 2007. Creatine supplementation and exercise. J. Int. Soc. Sports Nutr. 4, 6 https://doi.org/10.1186/1550-2783-4-6
  4. Chun, S. H. 2004. Devlopment and therapeutic perspective of type 2 Diabetes Mellitus. Biochem. Mol. Biol. News 9, 204-219
  5. Davis, A., M. Christiansen, J. F. Horowitz, S. Klein, M. K. Hellerstein, R. E. Ostlund Jr. 2000. Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care 23, 1000-1005 https://doi.org/10.2337/diacare.23.7.1000
  6. Farese, R. V., M. L. Standaert, K. Yamada, L. C. Huang, C. Zhang, D. R. Cooper, Z. Wang, Y. Yang, S. Suzuki, T. Toyota and J. Larner. 1994. Insulin-induced activation of glycerol-3-phosphate acyl- transferase by a chiro-inositol containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Proc. Natl. Acad. Sci. USA 91, 11040-11044 https://doi.org/10.1073/pnas.91.23.11040
  7. Fonteles, M. C., M. Q. Almeida and J. Larner. 2000. Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with managanese in streptozotocin diabetic rats. Horm. Metab. Res. 32, 129-132 https://doi.org/10.1055/s-2007-978606
  8. Fontales, M. C., L. C. Huang and J. Larner. 1996. Infusion of pH 2.0 D-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycaemia. Diabetologia 39, 731-734 https://doi.org/10.1007/BF00418546
  9. Gu, F., D. T. Nguyen, M. Stuible, N. Dube, M. L. Tremblay and E. Chevet. 2004. Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J. Biol. Chem. 279, 49689-49693 https://doi.org/10.1074/jbc.C400261200
  10. Huang, L. C., M. C. M. C. Fonteles, D. B. Houston, C. Zhang and J. Larner. 1993. Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo. Endocrinology 132, 652-657 https://doi.org/10.1210/en.132.2.652
  11. Iuorno, M. J., D. J. Jakubowicz, J.-P. Patrice, P. Dillone, R. D. Gunn, G.. Allan and J. E. Nestler. 2002. Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome. Endocrine Practice 8, 417-423 https://doi.org/10.4158/EP.8.6.417
  12. Jarret, L., E. H. A. Wong and J. A. Smith. 1985. Insulin mediator from rat skeletal muscle have differential effect on insulin-sensitive pathway of infact adipocytes. Science 227, 533-535 https://doi.org/10.1126/science.3917578
  13. Kang, M. J., J. I. Kim, S. Y. Yoon, J. C. Kim and I. J. Cha. 2006. Pinitol from reduces postprandial blood glucose in patients with type 2 Diabetes Mellitus. J. Med. Food 9, 182-186 https://doi.org/10.1089/jmf.2006.9.182
  14. Kennington, A. S., C. R. Hill, J. Craig, C. Bogardus, I. Raz, H. K. Ortmeyer, B. C. Hansen, G. Romero and J. Larner. 1990. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. New Eng. J. Med. 323, 373-378 https://doi.org/10.1056/NEJM199008093230603
  15. Kim, J. I., J. C. Kim, M. J. Kang, M. S. Lee, J. J. Kim and I. J. Cha. 2005. Effect of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur. J. Clin. Nutr. 59, 456-458 https://doi.org/10.1038/sj.ejcn.1602081
  16. Kim, M. J., K. H. Yoo, H. S. Park, S. M. Jeong, C. J. Jin, Y. S. Choi and C. H. Jeong. 2005. Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 Diabetes Mellitus. Diabetes 29, 344-351
  17. Kipfer-Coudreau, S. D., Eberlé, M. Sahbatou, A. Bonhomme, B. Guy-Grand, P. Froguel, P. Galan, A. Basdevant and K. Clément. 2004. Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects. Diabetologia 47, 1278-1284
  18. Larner, J., L. C. Huang, C. F. Schwartz, A. S. Oswald, T. Y. Shen, M. Kinter, G. Tang and K. Zeller. 1988. Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galac- tosamine and D-chiroinositol. Biochem. Biophys. Res. Commun. 151, 1416-1426 https://doi.org/10.1016/S0006-291X(88)80520-5
  19. Lee, D. T. and W. Y. Lee. 2005. Effect of pinitol supplementation and strength training on anaerobic performance and status of energy substrates in healthy young men. Nutr. Sci. 8, 189-195
  20. Narayanan, C. R., D. D. Joshi, A. M. Mujumdar and V. V. Dhekne. 1987. Pinitol– a new anti-diabetic compound from the leaves of Bougainvillea spectabilis. Curr. Sci. 56, 139-141
  21. Ortmeyer, H. K., N. L. Bodkin, K. Lilley and J. Larner. 1993. Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated insulin resistance in spontaneously diabetic rhesus monkeys. Endocrinology 132, 640-645 https://doi.org/10.1210/en.132.2.640
  22. Ortmeyer, H. K., L. C. Huang, H. L. Zhang, B. C. Hansen and J. Larner. 1993. Chiroinositol deficiency and insulin resistance. II. Acute effect of chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistance in spontaneously diabetic rhesus monkeys. Endocrinology 132, 646-651 https://doi.org/10.1210/en.132.2.646
  23. Ortmeyer, H. K., J. Larner and B. C. Hansen. 1995. Effects of D-chiroinositol added to a meal on plasma glucose and insulin in hyperinsulinemic rhesus monkeys. Obesity Res. 3, S605-S608 https://doi.org/10.1002/j.1550-8528.1995.tb00232.x
  24. Park, J. Y., K. J. Kim, J. H. Lee, K. P. Lee and M. K. Kim. 2005. Effect of feeding chitosan, Hibiscus extract and L-carnitine mixture on body weight and lipid metabolism in rats. Kor. J. Food Culture 20, 194-204
  25. Pak, Y., Y. Hong, S. Kim, T. Piccariello, R. V. Farese and J. Larner. 1998. In vivo chiro- inositol metabolism in rat: A defect in chiro-inositol synthesis from myo-inositol and an increased incorporation of chiro- [3H]inositol into phospholipids in the Goto-Kakizaki (G. K.) rat. Mol. Cells 8, 301-309
  26. Pak, Y., L. C. Huang, K. J. Lilley and J. Larner. 1992. In vivo conversion of [$^{3}H$]myo- inositol to [$^{3}H$]chiro-inositol in rat tissue. J. Biol. Chem. 267, 16904-16910
  27. Sethi, G., K. S. Ahn, B. Sung and B. B Aggarwal. 2008. Pinitol targets nuclear factor-kB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis. Mol. Cancer Ther. 7, 1604-1614 https://doi.org/10.1158/1535-7163.MCT-07-2424
  28. Sia, C. 2004. Spotlight on ethnomedicine: Usability of Sutherlandia flutescens in the treatment of diabetes. Rev. Diabetic Stud. 1, 145-149 https://doi.org/10.1900/RDS.2004.1.145
  29. Sohn, J. E., H. J. Koo and D. T. Lee. 2005. The effect of pinitol supplementation and resistance exercise on blood glucose level, physical characteristics, and physical fitness in elderly. Kor. J. Sports Nutr. 9, 189-194
  30. Suzuki, S., Y. Taneda, S. Hirasi, S. Abe, A. Sasaki, K. Suzuki and T. Toyata. 1991. pp. 197-203, Molecular mechanism of insulin resistance in spontaneous diabetic GK (Goto-Kakizaki) rats. New Directions in Research and Clinical Works for Obesity and Diabetes Mellitus, Elsevier Science Publishers
  31. Suzuki, S. and T. Toyota. 1994. Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes. Diabetes Care 17, 1465-1468 https://doi.org/10.2337/diacare.17.12.1465
  32. Viollet, B., R. Mounier, J. Leclerc, A. Yazigi, M. Foretz and F. Andreelli. 2007. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab. 33, 395-402 https://doi.org/10.1016/j.diabet.2007.10.004
  33. Zhan, T. and L. Hongxiang. 2007. Synthesis of azole nucleoside analogues of D-pinitol as potential antitumor agents. Carbohydrate Res. 342, 865-869 https://doi.org/10.1016/j.carres.2007.01.004