Journal of Genetic Medicine
- 제6권1호
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- Pages.62-66
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- 2009
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- 1226-1769(pISSN)
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- 2383-8442(eISSN)
자연 유산 수태산물의 세포유전학적 분석
A Cytogenetic Analysis of Abortus with Spontaneous Abortion
- Hwang, Si-Mok (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University) ;
- Kwon, Kyung-Hun (Division of Research and Development, GenDix, Inc.) ;
- Yoon, Kyung-Ah (Department of Clinical Pathology, Daejeon Health Sciences College) ;
- Oh, Sun-Kyung (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University)
- 투고 : 2009.05.27
- 심사 : 2009.06.23
- 발행 : 2009.03.01
초록
목 적: 자연 유산의 가장 흔한 원인은 수태산물의 염색체 이상으로 알려져 왔다. 따라서 환자들의 상담 및 치료에 유용한 정보를 얻기 위해 염색체 이상의 빈도와 유형을 조사하였다. 대상 및 방법: 2006년1월부터2007년 12월까지 수탁된 75례의 자연유산 수태산물에서 세포유전학적 분석을 수행하였다. 결 과: 수태산물의 염색체 이상 빈도는 32.0% (24/75례)였다. 염색체 이상들 중 삼염색체는 62.5% (15/24례)였고, 대부분의 삼염색체로는 21번 염색체의 삼염색체가 26.6% (4/15례), 다음으로 흔한 이상으로는 22번 삼염색체가 3례, 20번 삼염색체가 2례였다. 비정상 핵형의 모성 나이의 평균은
Purpose: Chromosomal abnormalities of abortuses have been used to investigate common etiologies of spontaneous abortion, but the frequencies and types of spontaneous abortions have demonstrated considerable variation among different countries and races. Materials and Methods: A cytogenetic analysis of 75 abortuses was performed at GenDix, Inc. from January 2006 to December 2007. Results: The frequency of chromosome abnormalities in abortuses was 32.0% (24/75 cases). Among the chromosomal abnormalities, trisomy was present in 62.5% (15/24 cases) of cases and the most frequent trisomy was trisomy 21 with an occurrence rate of 26.6% (4/15 cases). The following was trisomy 22 (3/15 cases) and trisomy 20 (2/15 cases). The average maternal age for abnormal karyotypes was