Bulletin of the Korean Chemical Society

  • 제30권1호
  • /
  • Pages.119-123
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  • 2009
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and NO Production Inhibitory Activities of Ursolic Acid and Oleanolic Acid Derivatives

  • Kwon, Tae-Hoon (Department of Pharmaceutical Science & Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Lee, Bo-Mi (Department of Pharmaceutical Science & Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Chung, Sung-Hyun (Department of Pharmaceutical Science & Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim, Dong-Hyun (Department of Pharmaceutical Science & Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Lee, Yong-Sup (Department of Pharmaceutical Science & Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
  • 발행 : 2009.01.20
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초록

Structural modifications were performed on the C-3 and C-28 positions of ursolic acid and oleanolic acid and the NO production inhibitory activities of the resulting derivatives were evaluated. The SAR revealed that the ursolic acid and oleanolic acid derivatives 3a and 4a, which possessing methoxy group at C-3 position exhibit improved NO production inhibitory activity on LPS-induced RAW247 cells while showing less cytotoxicity than the parent compounds.

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  2. Anti-inflammatory and antioxidative effects of six pentacyclic triterpenes isolated from the Mexican copal resin of Bursera copallifera vol.16, pp.1, 2016, https://doi.org/10.1186/s12906-016-1397-1
  3. A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design, Synthesis, and Biological Evaluation vol.16, pp.9, 2015, https://doi.org/10.3390/ijms160921035
  4. ChemInform Abstract: Synthesis and NO Production Inhibitory Activities of Ursolic Acid and Oleanolic Acid Derivatives. vol.40, pp.29, 2009, https://doi.org/10.1002/chin.200929179
  5. Preventive effect of ursolic acid derivative on particulate matter 2.5‐induced chronic obstructive pulmonary disease involves suppression of lung inflammation vol.72, pp.4, 2009, https://doi.org/10.1002/iub.2201
  6. Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents vol.15, pp.None, 2021, https://doi.org/10.2147/dddt.s291784