Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Total Synthesis of Licochalcone E

  • Yoon, Goo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Liu, Zhiguo (Korea Institute of Science and Technology, Gangneung Institute) ;
  • Jeong, Hee-Jin (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Cheon, Seung-Hoon (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
  • Published : 2009.12.20
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Abstract

Total synthesis of (${\pm}$)-licochalcone E (1), an allyl retrochalcone isolated from roots of Glycyrrhiza inflata, has been achieved from 4-tetrahydropyranyloxyacetophenone (7) with (E)-2-methoxy-4-(2-methyl-2-butenyloxy)benzaldehyde (6) or (Z)-2-methoxy-4-(2-methyl-2-butenyloxy)-benzaldehyde (11) through a convergent strategy involving aldol condensation and Claisen rearrangement as key steps.

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References

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