Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Biological Evaluation of 4-Heteroaryl-2-amino-5-methylimidazole Analogs as NHE-1 Inhibitors

  • Lee, Sun-Kyung (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Yi, Kyu-Yang (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Lee, Byung-Ho (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Yoon, Boo-Soon (Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2009.11.20
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Abstract

To identify a non-acylguanidine NHE-1 inhibitor, an acylguanidne group was replaced with an imidazole group in the potent NHE-1 inhibitors with furan or benzothiphene core template, found from our previous studies. We synthesized and biologically evaluated 4-heteroaryl-2-amino-5-methylimidazole derivatives. All those imidazole compounds (16-18) represented the potent NHE-1 inhibitory activities, similar to the corresponding acylguanidine compounds.

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References

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