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Antihyperglycemic Effects of Methylenedisalicylic Acid

  • Bhattarai, Bharat Raj (Department of Chemistry, College of Natural Science, Inha University) ;
  • Lee, Keun-Hyeung (Department of Chemistry, College of Natural Science, Inha University) ;
  • Cho, Hyeong-Jin (Department of Chemistry, College of Natural Science, Inha University)
  • Published : 2009.12.20
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References

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  12. Mouse experiment: Twenty one mice (C57BL/6J Jms Slc, 4-wk old, male, 17 ~ 19 g, Japan SLC, Inc., Haruno Breeding branch, Japan) were individually housed and maintained in a 12 h light/ dark cycle at$22{\pm}2{^{\circ}C}$ Food and water were available ad libitum. A high fat diet (HFD, D12451, New Brunswick, NJ, USA) and low fat diet (LFD, D10012G, New Brunswick) containing 45% and 16% of the calories from fat, respectively, were either in pellet or powder form. All mice were acclimatized for 1 wk (LFD), with 14 mice fed a HFD for the first 8 wk of the study for the development of obesity and diabetes; the remaining 7 were fed a LFD. The mice assigned to the LFD group were maintained on this diet throughout the study as a lean control group. At week 8, all the HFD-fed mice were divided into two groups. Each group was then given a HFD or HFD plus MDSA for 4 wk. The concentration of MDSA in the diets was 5.0 g/kg of diet (0.5% w/w). The LFD was provided in pellet form throughout the experiment. Conversely, the obese/diabetic control and MDSA-treated mice groups were fed with a HFD powdered food mixed with 10% H2O to make a dough. For the treatment with MDSA, 2.5 g of MDSA was dissolved in H2O (50 mL containing 2.0 equivalents of NaOH solution), mixed in powdered food (500 g), and kneaded to form a dough. Body weight and food intake were recorded every 3 d throughout the study. For the glucose tolerance test, mice were fasted for 6 h and glucose (1.0 g/kg of body weight) injected intraperitoneally. Blood glucose levels were measured from tail bleeds with a glucometer (Accu check active, Roche diagnostics, Ireland) at 0 (prior to glucose administration), 20, 40, 60, 90, and 120 min after glucose injection. After a 5 d recovery period on their own diet (the test group on HFD plus MDSA), mice were fasted overnight and blood collected by cardiac puncture under secobarbital anesthesia. Liver, lung, kidney, and white adipose tissue were excised and weighed. Plasma was analyzed for glucose, triglyceride, total cholesterol and free fatty acids using diagnostic kits (Glucose C2, TG E, T-Cho E and NEFA C from Wako Pure Chemical Industries, Ltd. Osaka, Japan)
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