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Synthesis of 3'(β)-C-methyl Carbodine Analogues as Potential Anti-HCV Agents

  • Li, Hua (BK21- Project Team, College of Pharmacy, Chosun University) ;
  • Baik, Young-Chan (Hawon Pharmaceuticals Co.,) ;
  • Hong, Joon-Hee (BK21- Project Team, College of Pharmacy, Chosun University)
  • 발행 : 2009.05.20

초록

The synthetic route of novel 3′-C-methyl carbodine analogue is described. The construction of tertiary alcohol at 3′- position of carbodine analogues was successfully made via sequential [3,3]-sigmatropic rearrangement, ring-closing metathesis (RCM) and stereoselective dihydroxylation reactions starting from ethyl glycolate.

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피인용 문헌

  1. ChemInform Abstract: Synthesis of 3′(β)-C-Methyl Carbodine Analogues as Potential anti-HCV Agents vol.40, pp.39, 2009, https://doi.org/10.1002/chin.200939199
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  3. Synthesis and Anti-HCV Activity of 3',5'-cyclic SATE Phosphonodiester Nucleoside as a Novel Prodrug vol.31, pp.4, 2009, https://doi.org/10.5012/bkcs.2010.31.04.915
  4. Design and Synthesis of Novel Carbocyclic Versions of 2′-spirocyclopropyl Ribonucleosides as Potent Anti-HCV Agents vol.30, pp.6, 2009, https://doi.org/10.1080/15257770.2011.587490