Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
권호 표지
DOI QR코드

DOI QR Code

A Thermodynamic Study of New Designed Complex of Ethylendiamine 8-Hydroxyquinolinato Palladium(II) Chloride with Calf Thymus DNA

  • Saeidfar, M. (Chemistry department, University of Sistan & Baluchestan) ;
  • Masouri-Torshizi, H. (Chemistry department, University of Sistan & Baluchestan) ;
  • Behbehani, G. Rezaei (Chemistry department, Imam Khomeini International University) ;
  • Divsalar, A. (Institute of Biochemistry and Biophysics, University of Tehran) ;
  • Saboury, A.A. (Institute of Biochemistry and Biophysics, University of Tehran)
  • Published : 2009.09.20
Download PDF
⟨ Previous Next ⟩

Abstract

A Thermodynamic study on the interaction of bovine calf thymus DNA with new designed Pd(II) complex (Ethylendiamine- 8-hydroxyquinolinato Palladium(II) chloride) was studied by using isothermal titration calorimetry (ITC) at 27 ${^{\circ}C}$ in Tris buffer solution at pH = 7.5. The enthalpies of Pd(II) complex + DNA interaction are reported and analysed in terms of the new solvation theory. It was indicated that there are three identical and non-cooperative sites for Pd(II) complex. The binding of a Pd(II) complex is endothermic with association equilibrium constants of 428.03 m$M^{-1}$ at 27 ${^{\circ}C}$. The binding of Pd(II) complex can cause some changes in the stability of the DNA at low and high Pd(II) complex concentrations. Our results suggested that this complex might interact with DNA as an intercalator, thus interfering with DNA replication and cell proliferation.

Keywords

References

  1. Bajdichova, M.; Busa, J.; Podhradsky, D.; Imrich, J. Int. J. Biol. Macromol. 2007, 41, 415 https://doi.org/10.1016/j.ijbiomac.2007.05.013
  2. Lemke, K.; Wojciechowski, M.; Laine, W.; Bailly, C.; Colson, P.; Baginski, M.; Larsen, A.; Skladanowski, A. Nucl. Acids. Res. 2005, 33, 6034 https://doi.org/10.1093/nar/gki904
  3. Perez-Flores, L.; Ruiz-Chica, A. J.; Delcros, J. G.; Sanchez-Jimene,F. M.; Ramírez, F. J. Spectrochim. Acta. Part A 2008, 69, 1089. https://doi.org/10.1016/j.saa.2007.06.008
  4. Larsen, A. K.; Escargueil, A. E.; Skladanowski, A. Pharmacol. Ther. 2003, 99, 167 https://doi.org/10.1016/S0163-7258(03)00058-5
  5. Marco, E.; Laine, W.; Tardy, C.; Lansiaux, E.; Iwao, M.; Ishibashi, F.; Bailly, C.; Gago, F. J. Med. Chem. 2005, 48, 3796 https://doi.org/10.1021/jm049060w
  6. Fox, K. R.; Harrison, N. K.; Waring, M. J. FEBS Lett. 1981, 133, 305 https://doi.org/10.1016/0014-5793(81)80530-3
  7. Metcalfe, C.; Thomas, J. A. Chem. Soc. Rev. 2003, 32, 215 https://doi.org/10.1039/b201945k
  8. Graves, D. E.; Velea, L. M. Curr. Org. Chem. 2000, 4, 915 https://doi.org/10.2174/1385272003375978
  9. McDonald, L. A.; Eldredge, G. S.; Barrows, L. R.; Ireland, C. M. J. Med. Chem. 1994, 37, 3819 https://doi.org/10.1021/jm00048a017
  10. Mandal, S.; Lloret, F.; Mukherjee, R. Inorg. Chim. Acta 2008, 362, 27 https://doi.org/10.1016/j.ica.2008.02.072
  11. Arounaguiri, S.; Maiya, B. G. Inorg. Chem. 1999, 38, 842 https://doi.org/10.1021/ic981109z
  12. Divsalar, A.; Saboury, A. A.; Yousefi, R.; Moosavi-Movahedi, A. A.; Mansoori-Torshizi, H. Int. J. Biol. Macromol. 2007, 40, 381 https://doi.org/10.1016/j.ijbiomac.2006.09.015
  13. Divsalar, A.; Saboury, A. A.; Moosavi-Movahedi, A. A.; Mansoori- Torshizi, H. J. Biomol. Struct. Dyn. 2007, 25, 1 https://doi.org/10.1080/07391102.2007.10507150
  14. Mansouri-Torshizi, H.; I-Moghaddam, M.; Divsalar, A.; Saboury, A. A. Bioorg. Med. Chem. 2008, 16, 9616 https://doi.org/10.1016/j.bmc.2008.08.021
  15. Mansouri-Torshizi, H.; I-Moghaddam, M.; Saboury, A. A. Acta Biochim. Biophys. Si. 2003, 35, 886
  16. Saboury, A. A. J. Therm. Anal. Cal. 2003, 72, 93 https://doi.org/10.1023/A:1023955300221
  17. Rezaei Behbehani, G.; Ghamamy, S.: Waghorne, W. E. Thermochim. Acta 2006, 448, 37 https://doi.org/10.1016/j.tca.2006.06.021
  18. Rezaei Behbehani, G.; Tazikeh, E.; Saboury, A. A. Acta Chim. Slov. 2006, 53, 363
  19. Rezaei Behbehani, G.; Saboury, A. A. Thermochim. Acta 2007, 452, 76 https://doi.org/10.1016/j.tca.2006.10.024
  20. Rezaei Behbehani, G.; Saboury, A. A.; Fallah baghery, A. J. Solution Chem. 2007, 36, 1311 https://doi.org/10.1007/s10953-007-9181-y
  21. Rezaei Behbehani, G.; Saboury, A. A.; Taleshi, E. J. Solution Chem. 2008, 37, 619 https://doi.org/10.1007/s10953-008-9267-1
  22. Rezaei Behbehani, G.; Saboury, A. A. J. Therm. Anal. Calorim. 2007, 89, 859
  23. Rezaei Behbehani, G.; Saboury, A. A.; Takeshi, E. J. Mol. Recognit. 2008, 21, 132 https://doi.org/10.1002/jmr.881
  24. Rezaei Behbehani, G.; Saboury, A. A. J. Coll. Surf. B: Biointerfaces 2007, 61, 224
  25. Rezaei Behbehani, G.; Divsalar, A.; Bagheri, M. J.; Saboury, A. A. J. Solution Chem. 2008, 37, 1785 https://doi.org/10.1007/s10953-008-9322-y
  26. Rezaei Behbehani, G.; Divsalar, A.; Saboury, A. A.; Gheibi, N. J. Solution Chem. 2008, 37, 1645 https://doi.org/10.1007/s10953-008-9339-2
  27. Hossain, Z.; Huq, F. J. Inorg. Biochem. 2002, 90, 85 https://doi.org/10.1016/S0162-0134(02)00412-9

Cited by

  1. Survey of the year 2009: applications of isothermal titration calorimetry vol.24, pp.1, 2011, https://doi.org/10.1002/jmr.1073
  2. DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes vol.2011, pp.1687-479X, 2011, https://doi.org/10.1155/2011/394506
  3. DNA Binding Studies and Cytotoxicity of Ethylenediamine 8-Hydroxyquinolinato Palladium(II) Chloride vol.57, pp.6, 2013, https://doi.org/10.1002/jccs.201000192
  4. , palladacycles and related complexes vol.43, pp.13, 2014, https://doi.org/10.1039/C4CS00063C
  5. Palladium complexes: new candidates for anti-cancer drugs vol.13, pp.5, 2016, https://doi.org/10.1007/s13738-015-0804-8
  6. Synthesis, characterization, cytotoxicity, DNA binding and computational studies of an anionic palladium(II) complex derived from 8-hydroxyquinoline and 1,1-cyclobutanedicarboxylate vol.15, pp.3, 2018, https://doi.org/10.1007/s13738-017-1269-8
  7. DNA-Binding and Thermodynamic Parameters, Structure and Cytotoxicity of Newly Designed Platinum(II) and Palladium(II) Anti-Tumor Complexes vol.32, pp.3, 2009, https://doi.org/10.5012/bkcs.2011.32.3.947
  8. Heteroleptic Pd(II) dithiocarbamates: synthesis, characterization, packing and in vitro anticancer activity against HeLa cell line vol.68, pp.14, 2015, https://doi.org/10.1080/00958972.2015.1054817
  9. Investigating the Apoptosis Ability of Ethylenediamine 8-Hydroxyquinolinato Palladium (II) Complex vol.6, pp.3, 2009, https://doi.org/10.15171/apb.2016.058
  10. Synthesis of PdO nanoparticles: Crystal structure, DNA binding, and cytotoxicity of a new hydroxyl-quinolinato-palladium complex vol.47, pp.4, 2009, https://doi.org/10.1080/15533174.2016.1186079
  11. 3′‐Methyl‐4‐thio‐1H‐tetrahydropyranspiro‐5′‐hydantoin platinum complex as a novel potent anticancer agent and xanthine oxidase inhibitor vol.353, pp.7, 2009, https://doi.org/10.1002/ardp.202000039
  12. Synthesis, characterization, DNA binding, cytotoxicity, and molecular docking approaches of Pd(II) complex with N,O- donor ligands as a novel potent anticancer agent vol.1215, pp.None, 2020, https://doi.org/10.1016/j.molstruc.2020.128212
  13. Spectral and molecular docking studies of nucleic acids/protein binding interactions of a novel organometallic palladium (II) complex containing bioactive PTA ligands: Its synthesis, anticancer effect vol.34, pp.10, 2020, https://doi.org/10.1002/aoc.5839