Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Antibacterial Activity of 1,3-Diallyltrisulfane Derivatives

  • Ren, Fang-Kui (College of Pharmaceutical Sciences, Southwest University) ;
  • He, Xiao-Yan (College of Pharmaceutical Sciences, Southwest University) ;
  • Deng, Li (College of Pharmaceutical Sciences, Southwest University) ;
  • Li, Bo-Heng (High School Attached to Southwest Normal University) ;
  • Shin, Dong-Soo (Department of Chemistry, Changwon National University) ;
  • Li, Zhu-Bo (College of Pharmaceutical Sciences, Southwest University)
  • Published : 2009.03.20
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Abstract

A series of novel 1,3-diallyltrisulfane analogues were synthesized and assayed in vitro for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The antimicrobial activity of the 1,3-diallyltrisulfane derivatives showed, on the whole, very potent towards all the tested Gram positive, Gram negative and fungi (MIC ranging from 4 to 256 μg/mL). 1,3-Di(pent-4-enyl)trisulfane 3b and 1,3-bis(3-methylbut-2-enyl)trisulfane 3e exhibited the strongest antibacterial activity among all the compounds, and both of them were more active than 1,3-diallyltrisulfane (DATS). Results indicated the relationship of either carbon number or lipophilicity with antimicrobial activity presented “V” shape. These observations provided some predictions in order to further design 1,3-diallyltrisulfane derivatives with antimicrobial activity.

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