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Comparison of Clinical Efficacy between an HPV DNA Chip and a Hybrid-Capture II Assay in a Patient with Abnormal Colposcopic Findings

질 확대경상 비정상 소견을 보인 환자에서 HPV DNA chip과 Hybrid-Capture II assay의 임상적 유용성 비교

  • Kim, Tae-Jung (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Jung, Chan-Kwon (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Ah-Won (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Jung, Eun-Sun (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Choi, Young-Jin (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Kyo-Young (Department of Hospital Pathology, College of Medicine, The Catholic University of Korea) ;
  • Park, Jong-Sup (Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea)
  • 김태정 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 정찬권 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 이아원 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 정은선 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 최영진 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 이교영 (가톨릭대학교 의과대학 병원병리학교실) ;
  • 박종섭 (가톨릭대학교 의과대학 산부인과학교실)
  • Published : 2008.09.30

Abstract

This study was performed to compare the efficacy between a DNA chip method and a Hybrid-Capture II assay (HC-II) for detecting human papillomavirus in patients with intraepithelial lesions of the uterine cervix. From May, 2005, to June, 2006, 192 patients with abnormal colposcopic findings received cervical cytology, HC-II and HPV DNA chip tests, and colposcopic biopsy or conization. We compared the results of HC-II and HPV DNA chip in conjunction with liquid based cervical cytology (LBCC) and confirmed the results of biopsy or conization. The sensitivity of the HPV DNA chip test was higher than HC-II or LBCC. The HPV DNA chip in conjunction with LBCC showed higher sensitivity than any single method and higher sensitivity than HC-II with LBCC. We confirmed that the HPV DNA chip test was more sensitive for detecting HPV in cervical lesions than HC-II, and that it would provide more useful clinical information about HPV type and its multiple infections.

Keywords

References

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