Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Screening for Human ACAT-1 and ACAT-2 Inhibitory Activity of Edible Plant Extracts

식물추출물의 Human-ACAT 저해활성 검색

  • Lee, Dae-Young (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University) ;
  • Jeong, Tae-Sook (National research Laboratory of Lipid Metabolism & Atherosclerosis, Korea research Institute of Bioscience and Biotechnology) ;
  • Lyu, Ha-Na (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University) ;
  • Bang, Myun-Ho (Plant Metabolism research Center and Institute of Life Science & resources, KyungHee University) ;
  • Hong, Yoon-Hee (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University) ;
  • Lee, Youn-Hyung (Department of Horticultural Biotechnology, KyungHee University) ;
  • Baek, Nam-In (Plant Metabolism Research Center and Institute of Life Science & Resources, KyungHee University)
  • 이대영 (경희대학교 식물대사 연구센터 및 생명자원과학연구원) ;
  • 정태숙 (한국생명공학연구원 지질대사 연구센터) ;
  • 류하나 (경희대학교 식물대사 연구센터 및 생명자원과학연구원) ;
  • 방면호 (경희대학교 식물대사 연구센터 및 생명자원과학연구원) ;
  • 홍윤희 (경희대학교 식물대사 연구센터 및 생명자원과학연구원) ;
  • 이윤형 (경희대학교 원예학과) ;
  • 백남인 (경희대학교 식물대사 연구센터 및 생명자원과학연구원)
  • Published : 2008.10.30
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Abstract

Cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Inhibitory effects on ACAT of the MeOH extracts prepared from 163 edible plants were evaluated. 15 species out of 163 species exhibited higher than 50% of inhibition on the hACAT-1 and 9 species exhibited higher than 50% of inhibition on the hACAT-2 activity at their concentration of $100\;{\mu}g/mL$.

Keywords

References

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