Biomedical Science Letters (대한의생명과학회지)
- Volume 14 Issue 3
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- Pages.187-192
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- 2008
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Protective Effect of Omega-3 of Polyunsaturated Fatty Acid Docosahexaenoic Acid on the Organic Mercury-Induced Cytotoxicity in Cultured NIH3T3 Fibroblasts
- Ha, Dae-Ho (Sanbon Medical Center, Wonkwang University) ;
- Lee, Jai-Kyoo (Sanbon Medical Center, Wonkwang University)
- Published : 2008.09.30
Abstract
To clerify the protective effect of omega-3 of polyunsaturated fatty acid docosahexaenoic acid (DHA) on the cytotoxicity induced by organic mercury in cultured NIH3T3 fibroblasts. The measurement of cell viability on ogranic mercury wad done by XTT assay after NIH3T3 fibroblasts were cultured with various concentrations of methyl mercuric chloride (MMC). And also, the effect of DHA on the MMC-mediated cytotoxicity was examined by cell viability, and antioxidant effect of DHA was also assessed by superoxide dismutase (SOD)-like activity and the lipid peroxidation activity in cultured NIH3T3 fibroblasts. In this study, MMC decreased cell viability and