Biomedical Science Letters (대한의생명과학회지)
- Volume 14 Issue 3
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- Pages.147-155
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- 2008
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Taxifolin Inhibited the Nitric Oxide Production and Expression of Pro-inflammatory Cytokine mRNA in Lipopolysaccharide-stimulated RAW264.7 Cells
- Rhee, Man-Hee (Laboratory of Physiology & Signaling, College of Veterinary Medicine, Kyungpook National University) ;
- Endale, Mehari (Laboratory of Physiology & Signaling, College of Veterinary Medicine, Kyungpook National University) ;
- Kamruzzaman, SM (Laboratory of Physiology & Signaling, College of Veterinary Medicine, Kyungpook National University) ;
- Lee, Whi-Min (Laboratory of Physiology & Signaling, College of Veterinary Medicine, Kyungpook National University) ;
- Park, Hwa-Jin (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University) ;
- Yoo, Myung-Jo (College of Veterinary Medicine, Chonbuk National University) ;
- Cho, Jae-Youl (School of Biotechnology and Bioengineering, Kangwon National University)
- Published : 2008.09.30
Abstract
In previous works, we found that solvent extract of Opuntia humifusa Raf., a member of the lactaceae family, displayed potent anti-oxidative and anti-inflammatory activities. Thus, all solvent fractions, except for the water layer, showed potent scavenging effects. According to activity-guided fractionation, one of active radical scavenging principles in the ethyl acetate fraction was found to be taxifolin. In this study, we investigated whether taxifolin showed anti-oxidative activity. In addition, taxifolin modulated nitric oxide (NO) release and the expression of pro-inflammatory cytokine mRNA such as interleukin-
Keywords
- Taxifolin;
- Opuntia humifusa Raf;
- Anti-oxidative activity;
- Anti-inflammatory activity;
- Nitric oxide;
- Pro- inflammatory cytokines