한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제18권1호
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- Pages.6-10
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- 2008
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
흰쥐에서 베라파밀과 장기투여된 피오그리타존과의 약물상호작용
Drug Interaction Between Verapamil and Pioglitazone Long-term Administered to Rats
- Choi, Dong-Hyun (College of Medicine, Chosun University) ;
- Kim, Hyun-Yong (College of Pharmacy, Chosun University) ;
- Choi, Jun-Shik (College of Pharmacy, Chosun University)
- 발행 : 2008.06.30
초록
This study investigated the effect of long-term administration of pioglitazone on the pharmacokinetics of verapamil in rats. Pharmacokinetic parameters of verapamil were determined after oral administration of verapamil (9 mg/kg) in rats coadministered pioglitazone (0.5 mg/kg) or pretreated with pioglitazone (0.5 mg/kg) for 3 and 9 days. Compared to oral control group, the presence of pioglitazone significantly (p<0.05) increased the area under the plasma concentration-time curve (AUC) of verapamil by 48.6% (coad), 61.1% (3 days) and 56.5% (9 days), and the peak concentration(