Mycobiology

The Korean Society of Mycology (한국균학회)
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Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom

  • Seo, Dong-Soo (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Lee, Eun-Na (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Seo, Geon-Sik (Korea National Agricultural College) ;
  • Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
  • Published : 2008.09.30
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Abstract

To produce a potent antidementia $\beta$-secretase inhibitor from a mushroom, the $\beta$-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40$^{\circ}C$ for 24 h.

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References

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