Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

A COMPARATIVE STUDY OF VARIOUS TYPE OF AUTOGENEOUS BONE GRAFT ON THE RABBIT-SKULL DEFECT HEALING

가토 두개골에 이식한 다양한 형태의 자가골에 의한 골성 회복 양상 비교 평가

  • Choi, So-Young (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Lee, Su-Youn (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Kim, Jin-Wook (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Kim, Chin-Soo (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Lee, Sang-Han (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) ;
  • Shin, Hong-In (IHBR, Dept. of Oral Pathology, School of Dentistry, Kyungpook National University) ;
  • Kwon, Tae-Geon (Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University)
  • 최소영 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 이수연 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 김진욱 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 김진수 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 이상한 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 신홍인 (경북대학교 치과대학 경조직-바이오치아 재생 연구소, 구강병리학교실) ;
  • 권대근 (경북대학교 치과대학 구강악안면외과학교실)
  • Published : 2008.08.29
Download PDF
⟨ Previous Next ⟩

Abstract

Introduction: Piezosurgery device is one of the most commonly used instrument on the intraoral surgery such as maxillary sinus lift and autogeneous bone graft. Piezosurgery instrument also contains the tips that are manufactured especially for the convenient bone graft, which now many surgeons apply them for collecting bone graft materials in the curettage method for the restoration of skull defects. However, objective data has not been shown concerning the effects about bone graft with using Piezosurgery. Therefore we investigated the effects of Piezosurgery on the rabbit-skull defect healing. Materials & Methods: To investigate the regeneration of the bony defect with various bone graft, 10 adult New Zealand white rabbits (average weight : $2.8{\pm}0.3kg$, about 12weeks) were used. The four circular bony defects measuring 6mm in diameter were made with Piezosurgery device on each rabbit cranial bone. The harvested bone tissues during defect formation were also used for autogeneous bone graft. They were grafted into the defects in a various type; block type (Group 1), particulated type by the bone mill (Group 2), chopped type by curette shaped Piezosurgery tip (Group 3), the defect without any graft was served as control (control group). The animals were sacrificed after 6 weeks and bone regeneration capacity was evaluated histomorphometrically. Result & Conclusion: Autogeneous bone graft harvested using a Piezosurgery instrument showed satisfactory bone regeneration. There was no conspicuous difference bone prepared among by bone mill or Piezosurgery and block bone graft. Therefore, the bone harvested from the intraoral site near the operation field using the piezosurgery device can be a feasible and reliable graft for intraoral bony defects.

Keywords

References

  1. Hopp SG, Dahners LE, Gilbert JA: A study of the mechanical strength of long bone defects treated with various bone autograft substitutes : An experimental investigation in the rabbit. J Orthop Res 1989;7:579-584 https://doi.org/10.1002/jor.1100070416
  2. Goldberg VM, Stevenson S: Nature history of autograft and allograft. Clin Orthop 1987;7:225
  3. Arrington ED, Smith WJ, Chambers HG: Complications of iliac crest bone graft harvesting. Clin Orthop 1996;329:300-309 https://doi.org/10.1097/00003086-199608000-00037
  4. Mulliken JB, Glowacki J, Kaban LB, Forkman J, Murray JE: Application of demineralized allogenic bone implants for the correction of maxillocranial facial deformities. Ann Surg 1981;3:633
  5. Kainulainen V, Oikarinen K: Comparison of four bone collectors designed for oral and maxillofacial surgery : An in vitro study. Clin Oral Implants Res 1998;9:327-324 https://doi.org/10.1034/j.1600-0501.1998.090506.x
  6. Hoigne DJ, St¨ubinger S, Kaenel OV, Shamdasani S, Hasenboehler P: Piezoelectric osteotomy in hand surgery: First experiences with a new technique. BMC Musculoskeletal Disorders 2006;7:36 https://doi.org/10.1186/1471-2474-7-36
  7. Stubinger S, Kuttenberger J, Filippi A, Sader R, Zeilhofer HF:Intraoral Piezosurgery : Preliminary results of a new technique. J Oral Maxillofac Surg 2005;63:1283-1287 https://doi.org/10.1016/j.joms.2005.05.304
  8. Akita S, Fukui M, Nakagawa H, Fujii T, Akino K: Cranial bone defect healing is accelerated by mesenchymal stem cells induced by coadministration of bone morphogenetic protein-2 and basic fibroblast growth factor. Wound Repair Regen 2004;12:252-259 https://doi.org/10.1111/j.1067-1927.2004.012118.x
  9. Sohn DS, Ahn MR, Lee WH, Yeo DS, Lim SY: Piezoelectric osteotomy for intraoral harvesting of bone blocks. Int J Periodontics Restorative Dent 2007;27:127-131
  10. Siervo S, Ruggli-Milic S, Radici M, Siervo P, Ja¨ger K: Piezoelectric surgery. : An alternative method of minimally invasive surgery. Schweiz Monatsschr Zahnmed 2004;114:365-377
  11. Chiriac G, Herten M, Schwarz F, Rothamel D, Becker J: Autogenous bone chips: Influence of a new piezoelectric device (Piezosurgery) on chip morphology, cell viability and differentiation. J Clin Periodontol 2005;32:994-999 https://doi.org/10.1111/j.1600-051X.2005.00809.x
  12. Urist MR, Silverman BF, B¨uring K, Dubuc FL, Rosenberg JM: The bone induction principle. Clin Orthop Relat Res 1967;53:243
  13. Rivault AF, Toto PD, Levy S, Gargiulo AW: Autogenous bone grafts : Osseous coagulum and osseous retrograde procedures in primates. J Periodontol 1971;42:787-796 https://doi.org/10.1902/jop.1971.42.12.787
  14. Jonk LM: bone induction effect of fine bone shavings in polyester fiber. An experimental study. S Afr Med J 1975;49:697-702
  15. Shapoff CA, Bowers GM, Levy B, Mellonig JT, Yukna RA: The effect of particle size on the osteogenic activity of composite grafts of allogeneic freeze-dried bone and autogenous marrow. J Periodontol 1980;51:625-630 https://doi.org/10.1902/jop.1980.51.11.625
  16. Pallesen L, Schou S, Aaboe M, Hjorting-Hansen E, Nattestad A, Melsen F: Influence of particle size of autogenous bone grafts on the early stages of bone regeneration: A histologic and stereologic study in rabbit calvarium. Int J Oral Maxillofac Implants 2002;17:498-506
  17. Sivolella S, Berengo M, Scarin M, Mella F, Martinelli F: Autogenous particulate bone collected with a Piezo-electric surgical device and bone trap: A microbiological and histomorphometric study. Arch Oral Biol 2006;51:883-891 https://doi.org/10.1016/j.archoralbio.2006.04.001
  18. Schepers EJ, Ducheyne P: Bioactive glass particles of narrow size range for the treatment of oral bone defects : A 1-24 month experiment with several materials and particle sizes and size ranges. J Oral Rehabil 1997;24:171-181 https://doi.org/10.1111/j.1365-2842.1997.tb00311.x
  19. Xu H, Shimizu Y, Asai S, Ooya K: Experimental sinus grafting with the use of deproteinized bone particles of different sizes. Clin Oral Impl Res 2003;14:548-555 https://doi.org/10.1034/j.1600-0501.2003.00933.x
  20. Shand JM, Heggie AA, Holmes AD, Holmes W: Allogeneic bone grafting of calvarial defects: An experimental study in the rabbit. Int J Oral Maxillofac Surg. 2002;31:525-531 https://doi.org/10.1054/ijom.2002.0281
  21. Haddad AJ, Peel SA, Clokie CM, Sandor GK: Closure of rabbit calvarial critical-sized defects using protective composite allogeneic and alloplastic bone substitutes. J Craniofac Surg 2006;17:926-934 https://doi.org/10.1097/01.scs.0000230615.49270.d1
  22. Robiony M, Polini F, Costa F, Vercellotti T, Politi M: Piezoelectric bone cutting in multipiece maxillary osteotomies. J Oral Maxillofac Surg 2004;62:759-761 https://doi.org/10.1016/j.joms.2004.01.010
  23. Moghadam HG, Sandor GK, Holmes HH, Clokie CM: Histomorphometric evaluation of bone regeneration using allogeneic and alloplastic bone substitutes. J Oral Maxillofac Surg 2004;62:202-213 https://doi.org/10.1016/j.joms.2003.10.002
  24. Stal S, Tjelmeland K, Hicks J, Bhatia N, Eppley B, Hollier L: Compartmentalized bone regeneration of cranial defects with biodegradable barriers : An animal model. J Craniofac Surg 2001;12:41-47 https://doi.org/10.1097/00001665-200101000-00007
  25. Young MP, Worthington HV, Lloyd RE, Drucker DB, Sloan P, Carter DH: bone collected during dental implant surgery : A clinical and histological study. Clin Oral Implants Res 2002;13:298-303 https://doi.org/10.1034/j.1600-0501.2002.130310.x
  26. Oikarinen K, Kainulainen V, Kainulainen T: A method of harvesting corticocancellous bone chips for reconstructive maxillofacial surgery. Int J Oral Maxillofac Surg 1997;26:103-105
  27. Schlee M, Steigmann M, Bratu E, Garg AK: Piezosurgery basics and possibilities. Implant Dent. 2006;15:334-340 https://doi.org/10.1097/01.id.0000247859.86693.ef
  28. Lambrecht JT: Intraoral piezo-surgery. Schweiz Monatsschr Zahnmed. 2004;114:28-36
  29. Vercellotti T, Pollack AS: A new bone surgery device: Sinus grafting and periodontal surgery. Compend Contin Educ Dent 2006;27:319-325
  30. Clokie CM, Moghadam H, Jackson MT, Sandor GK: Closure of critical sized defects with allogenic and alloplastic bone substitutes. J Craniofac Surg 2002;13:111-121 https://doi.org/10.1097/00001665-200201000-00026