Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
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마우스 경구 및 경피투여에 의한 $SiO_2$ 나노입자의 체내분포

Tissue Distribution of $SiO_2$ Nanoparticles in Mice after Oral Administration or Skin Treatment

  • 박은정 (동덕여자대학교 약학대학) ;
  • 박광식 (동덕여자대학교 약학대학)
  • 발행 : 2008.06.30
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초록

Tissue distribution of $SiO_2$ nanopaprticles was investigated in mice after oral administration or skin treatment. ICR Male mice were treated with $SiO_2$ nanoparticles 2.5 g/kg/day for five consecutive days and sacrificed at 24 hours after the last administration. As results, the orally administered $SiO_2$ nanoparticels were distributed in the testis and kidney but not in lung at 24 hours after the last treatment. In case of skin treatment, $SiO_2$ nanoparticles were distributed to lung as well as testis, brain, kidney and liver. The results suggested that $SiO_2$ nanoparticles (12 nm) are easily absorbed through entero-gastric system or skin.

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참고문헌

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