Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Tissue Distribution of $SiO_2$ Nanoparticles in Mice after Oral Administration or Skin Treatment

마우스 경구 및 경피투여에 의한 $SiO_2$ 나노입자의 체내분포

  • 박은정 (동덕여자대학교 약학대학) ;
  • 박광식 (동덕여자대학교 약학대학)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Tissue distribution of $SiO_2$ nanopaprticles was investigated in mice after oral administration or skin treatment. ICR Male mice were treated with $SiO_2$ nanoparticles 2.5 g/kg/day for five consecutive days and sacrificed at 24 hours after the last administration. As results, the orally administered $SiO_2$ nanoparticels were distributed in the testis and kidney but not in lung at 24 hours after the last treatment. In case of skin treatment, $SiO_2$ nanoparticles were distributed to lung as well as testis, brain, kidney and liver. The results suggested that $SiO_2$ nanoparticles (12 nm) are easily absorbed through entero-gastric system or skin.

Keywords

References

  1. Barik TK, Sahu B and Swain V. Nanosilica-from medicine to pest control, Parasitol Res, 2008; 103(2): 253-258 https://doi.org/10.1007/s00436-008-0975-7
  2. Cha KE and Myung H. Cytotoxic effects of nanoparticles assessed in vitro and in vivo, J Microbiol Biotechnol, 2007; 17(9): 1573-1578
  3. Chang JS, Chang KL, Hwang DF and Kong ZL. In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line, Environ Sci Technol 2007; 41(6): 2064- 2068 https://doi.org/10.1021/es062347t
  4. Choi SJ, Oh JM, Park T and Choy JH. Cellular toxicity of inorganic hydroxide nanoparticles, J Nanosci Nanotechnol, 2007; 7(11): 4017-4020 https://doi.org/10.1166/jnn.2007.085
  5. Jin Y, Kannan S, Wu M and Zhao JX. Toxicity of luminescent silica nanoparticles to living cells, Chem Res Toxicol, 2007; 20(8): 1126-1133 https://doi.org/10.1021/tx7001959
  6. Oberdorster G, Oberdoster E and Oberdorster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005; 113 (7): 823-829 https://doi.org/10.1289/ehp.7339
  7. Park EJ, Choi J, Park YK and Park K. Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells, Toxicology, 2008; 245/1-2: 90-100 https://doi.org/10.1016/j.tox.2007.12.022
  8. Van Hoecke K, De Schamphelaere KA, Van der Meeren P, Lucas S and Janssen CR. Ecotoxicity of silica nanoparticles to the green alga Pseudokirchneriella subcapitata: importance of surface area. Environ Toxicol Chem 2008; (PMID: 18473604)