Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Aqueous Extracts of Walnut (Juglans regia L.) and Nelumbo nucifera Seeds Reduce Plasma Corticosterone Levels, Gastric Lesions, and c-fos Immunoreactivity in Chronic Restraint-stressed Mice

  • Kim, Dae-Won (Central Research Center, Natural F&P Co., Ltd.) ;
  • Hwang, In-Koo (Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Yoo, Ki-Yeon (Department of Anatomy and Neurobiology, College of Medicine, Hallym University) ;
  • Li, Hua (Department of Anatomy and Neurobiology, College of Medicine, Hallym University) ;
  • Kang, Il-Jun (Department of Food Science and Nutrition, Division of Life Science, Hallym University) ;
  • Moon, Won-Kuk (Central Research Center, Natural F&P Co., Ltd.) ;
  • Won, Moo-Ho (Department of Anatomy and Neurobiology, College of Medicine, Hallym University) ;
  • Kim, Seok-Joong (Department of Food and Nutrition, Dongduk Women's University) ;
  • Han, Dae-Seok (Food Processing and Post-harvest Technology Division, Korea Food Research Institute) ;
  • Kim, Dong-Woo (Central Research Center, Natural F&P Co., Ltd.)
  • Published : 2008.08.31
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Abstract

In the present study, chronic effects of the hot water extracts of walnut seed (Juglans regia L.) (WSE) and Nelumbo nucifera seed (NSE) were investigated in mice exposed to 2 hr of restraint stress each day for 4 weeks. Corticosterone levels in serum were significantly increased in the vehicle-treated stressed group ($25\;{\mu}g/dL$) compared to that in the control group ($13\;{\mu}g/dL$). This stress induced gastric redness and lesions. However, treatment with WSE and/or NSE significantly protected the stomach from this lesion by 50-60% compared to that in the vehicletreated group. In the amygdala, the administration of WSE and/or NSE also reduced the immediate early gene (c-fos) expression by 70-90% vs. the vehicle-treated group. These suggest that WSE and/or NSE may reduce the appearance of symptoms induced by stress and these materials are useful as anti-stress foods, as natural products tend to be relatively safe compared to chemical products.

Keywords

References

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