Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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FEATURES OF HISTOPATHOLOGIC AND RADIOGRAPHIC FINDINGS IN BISPHOSPHONATE-RELATED OSTEONECROSIS OF JAW-CLINICAL REVIEW

Bisphosphonate-related osteonecrosis of the jaw의 병리조직학적 소견 및 방사선학적 특징에 대한 임상적 고찰

  • Ohe, Joo-Young (Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental School) ;
  • Kwon, Yong-Dae (Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental School) ;
  • Kim, Yeo-Gab (Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental School) ;
  • Lee, Baek-Soo (Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental School) ;
  • Yoon, Byoung-Wook (Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental School) ;
  • Choi, Byoung-Jun (Department of Oral and Maxillofacial Surgery, Kyung Hee University Dental School)
  • 오주영 (경희대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 권용대 (경희대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김여갑 (경희대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 이백수 (경희대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 윤병욱 (경희대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 최병준 (경희대학교 치의학전문대학원 구강악안면외과학교실)
  • Published : 2008.10.31
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Abstract

Bisphosphonates (BPs) are a class of agent used to treat patient with osteoporosis or malignant bone metastases. BPs can be categorized into 2 groups: nitrogen-containing and non-nitrogen containing. Nitrogen-containing BPs are considered to have more toxicity. Despite their clinical benefits, bisphosphonate-related osteonecrosis of jaw(BRONJ) is a significant complication to patients receveing these drugs. Since the first description of BRONJ in 2003 by Marx, the number of reports on BRONJ has been rapidly increasing. BRONJ is considered as an emerging problem in oral & maxillofacial surgery. Generally, osteonecrosis in the maxilla is rare, however BRONJ is found both in the maxilla and the mandible. This is an important feature of BRONJ compared to common infectious osteomyelitis of the jaw. Growing number of case reports, suggest that bisphosphonate therapy may cause exposed, necrotic bone. BRONJ has simillar features compared to IORN (infected osteoradionecrosis). BRONJ has meaningful features established through the interestigation on histopathologic and radiographic findings. These features have an impact on treatment plan and prognosis. This presentation contemplates on features of histopathologic and radiographic findings in bisphosphonate-related osteonecrosis of the jaw.

Keywords

References

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