The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Protective Effects of Gami Yugan-tang on Liver Damage in Rats

흰쥐의 간손상(肝損傷)에 대한 가미유간탕(加味愈肝湯)의 간(肝) 보호효과(保護效果)

  • Jung, Hee (Department of Preventive Medicine, College of Oriental medicine, Kyunghee University) ;
  • Go, Ho-Yeon (Department of Internal Medicine, College of Oriental medicine, Kyungwon University) ;
  • Hsia, Yu-Chun (Department of Internal Medicine, Kyungwon University In-cheon Oriental Medical Hospital) ;
  • Yeo, Hyun-Soo (Department of Internal Medicine, College of Oriental medicine, Kyungwon University) ;
  • Baik, Jong-Woo (Department of Internal Medicine, Kyungwon University In-cheon Oriental Medical Hospital) ;
  • Ko, Seung-Gyu (Department of Preventive Medicine, College of Oriental medicine, Kyunghee University) ;
  • Park, Jong-Hyung (Department of Internal Medicine, Kyungwon University In-cheon Oriental Medical Hospital) ;
  • Jun, Chan-Yong (Department of Internal Medicine, College of Oriental medicine, Kyungwon University) ;
  • Kang, Jea-Chun (Kang Jea-Chun Oriental Medicine Clinic)
  • 정희 (경희대학교 한의과대학 예방의학교실) ;
  • 고호연 (경원대학교 한의과대학 내과학교실) ;
  • 하유군 (경원대학교 인천한방병원) ;
  • 여현수 (경원대학교 한의과대학 내과학교실) ;
  • 백종우 (경원대학교 인천한방병원) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실) ;
  • 박종형 (경원대학교 인천한방병원) ;
  • 전찬용 (경원대학교 한의과대학 내과학교실) ;
  • 강재춘 (강재춘한의원)
  • Published : 2008.03.31
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Abstract

In order to investigate the protective effects of Gami Yugan-tang on liver damage in rats induced by $CCl_{4}$ and d-galactosamine, the serum transaminase(ALT & AST), alkaline phosphatase(ALP), lactic dehydrogenase(LDH), superoxide dismutase(SOD), catalase, glutathione S-transferase(GST), glutathione peroxidase(GPX) for enzyme activities, and lipid peroxidation were measured. All animals were divided into 4 groups: normal group (untreated), control group (treated with 0.9% saline solution), sample I group (treated with 740mg/kg Gami Yugan-tang), and sample II group (treated with 1,480mg/kg Gami Yugan-tang). The results were as follows : 1. The results of liver damage in rats induced by $CCl_4$ : The protective effects of ALT were displayed in sample I and sample II, and AST, ALP, LDH, SOD, catalase, GST, GPX, and lipid peroxidation were noted in sample II group. It showed slight necrosis of hepatic cell and pathologic changes, for example, inflammatory cells infiltration were improved in sample II group compared to the control group. 2. The results of liver damage in rats induced by d-galactosamine : The inhibitory effects of AST, ALT, LDH, and ALP activities were noted in both sample I and sample II groups. The findings from this experiment suggests that Gami Yugan-tang has protective effects against liver damage in rats induced by $CCl_{4}$ and d-galactosamine.

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