The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 29 Issue 2
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- Pages.385-400
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- 2008
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- 1226-9174(pISSN)
The Effects of Soyumjungjang-tang on DSS-Induced Ulcerative Colitis in Mouse
소염정장탕(消炎整腸湯)이 DSS로 유발(誘發)된 생쥐의 궤양성 대장염에 미치는 영향(影響)
- Song, Young-Guen (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Ryu, Bong-Ha (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Yoon, Seong-Woo (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
- Published : 2008.06.30
Abstract
Objectives : This study was carried out to investigate the effects of Soyumjungjang-tang(SJT) on the experimental ulcerative colitis induced by dextran sulfate sodium(DSS) in mice. Methods : Ulcerative colitis was induced through supplying 4% DSS solution as the drinking water for 7 days in 6-week-old male ICR mice. The colitic mice were divided into three groups: the sample groups were orally administered SJT in doses of 25mg/kg(S25 group) or 100mg/kg(S100 group) once a day for 10 days, from 3 days before starting drinking the DSS solution, and the control(C) group was administered normal saline instead of SJT. The DSS solution or SJT was not administered to the normal(N) group. The length of colon, histologic finding, the activities of myeloperoxidase(MPO) and alkaline phosphatase(AP), and the expressions of