Applied Biological Chemistry

  • 제51권3호
  • /
  • Pages.183-187
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  • 2008
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  • 2468-0834(pISSN)
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  • 2468-0842(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
권호 표지

Alkyl thiosulfi(o)nate 화합물의 합성과 생리활성

Synthesis and Biological Activities of Aklyl Thiosulfi(o)nates

  • 정현진 (건국대학교 응용생물화학과) ;
  • 경규항 (세종대학교 식품공학과) ;
  • 정이숙 (아주대학교 의과대학) ;
  • 경석헌 (건국대학교 분자생명공학과)
  • Jung, Hyun-Jin (Department of Applied Biology & Chemistry Konkuk University) ;
  • Kyung, Kyu-Hang (Department of Food Science, Sejong University) ;
  • Jung, Yi-Sook (Department of Physiology, Department of Molecular Science & Technology, Ajou University) ;
  • Kyung, Suk-Hun (Department of Molecular Biotechnology, Konkuk University)
  • 발행 : 2008.09.30
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초록

본 연구에서는 마늘 중의 항미생물 작용을 가지고 있는 allyl-2-propenyl-1-thiosulfinate의 유사체들인 alkyl thiosulfinate 및 이의 산화물인 thiosulfonate화합물들을 합성하고 이들의 생물 활성을 검사하였다. Alkylsulfinate는 이황화 화합물(disulfide)를 유기 과산화산으로, 또 alkyl thiosulfonate는 thiosulfinite를 sodium periodate로 산화시켜 합성하였다. 합성한 모든 alkylthiosulfinate 및 alkyl thiosulfonate들은 Staphylococcus aureus B33에 대해서는 항세균성을, Candida utilis ATCC42416에 대해서는 항곰팡이성을 나타내었다. 나아가 이들 화합물들은 항산화성과 항응고 활성도 나타내었다.

Alkyl thiosulfi(o)nates, analogs of allyl-2-propene-1-thiosulfinate isolated from Allium sativum and having antibacterial activity, were chemically synthesized and their biological activities were investigated. Alkyl thiosulfinates were prepared by oxidation of corresponding disulfides with organic peroxy acid, while alkyl thiosulfonates could be obtained by oxidation of the alkyl thiosulfinates using sodium periodate. All synthetic thiosulfi(o)nates showed antibacterial activity against Staphylococcus aureus B33 and antifungal activity against Candida utilis ATCC42416. Further more synthetic alkyl thiosulfonates displayed antioxidant activity and have also prevention effect of platelet aggregation induced by collagen in rat.

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