Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Apolipoprotein E Phenotypes and the Relationship Among Lipid Levels, Nutrient Intakes, Lifestyles and Risk Factors Between Subjects with and without Hyperlipidemic Risk

Apolipoprotein E 다형성과 고지혈증 위험 유무에 따른 혈중 지질농도, 영양소 섭취, 생활습관 및 위험요인과의 관계

  • Lee, Jae-Eun (Graduate School of Education, Chung Ang University) ;
  • Cho, Sang-Woon (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd) ;
  • Kang, Ji-Yeon (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd) ;
  • Paek, Yun-Mi (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd) ;
  • Choi, Chang-Sun (Graduate School of Education, Chung Ang University) ;
  • Park, Yoo-Kyoung (Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Choi, Tae-In (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd)
  • 이재은 (중앙대학교 교육대학원) ;
  • 조상운 (한국수력원자력(주) 방사선보건연구원) ;
  • 강지연 (한국수력원자력(주) 방사선보건연구원) ;
  • 백윤미 (한국수력원자력(주) 방사선보건연구원) ;
  • 최창순 (중앙대학교 교육대학원) ;
  • 박유경 (경희대학교 동서의학대학원 의학영양학과) ;
  • 최태인 (한국수력원자력(주) 방사선보건연구원)
  • Published : 2008.07.30
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Abstract

This study was performed to investigate Apolipoprotein E phenotypes and the relationship among lipid levels, nutrient intakes, lifestyles and risk factors between subjects with and without hyperlipidemic risk. The data were collected from 675 industrial male workers who had completed annual medical examination. Compared to the normal group, the hyperlipidemic risk group in Apo E3 and E4 had significantly higher BMI (p < 0.05) and showed significantly higher body fat (%), waist circumference and WHR in all types of Apo E (p < 0.05). In addition, the hyperlipidemic risk group had significantly higher total cholesterol, LDL-cholesterol, triglyceride and AI than the normal group in all types of Apo E (p < 0.05). Intakes of protein, calcium, phosphorus, iron, vitamin A, vitamin B1, vitamin B2, vitamin C and niacin in Apo E3 were significantly lower in the hyperlipidemic risk group than in the normal group (p < 0.05). In the logistic regression analysis, after adjustment for other factors, Apo E2 + E4, waist and WHR were the significant risk factors associated with hyperlipidemia, but protein intakes were associated with significantly lower risks of hyperlipidemia (p < 0.05). In conclusion, genetic factor (Apo E2 or Apo E4), anthropometric index and nutrient intake seem to influence hyperlidemic risk. Further studies and efforts will be needed to evaluate the independent relationships among hyperlipidemic risk factors.

Keywords

References

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