Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Anti-inflammatory Effect of Hong Hua Za Pharmacupuncture on Rheumatoid Arthritis that Caused by Lipopolysaccharide in Mouse

홍화자약침(紅花子藥鍼)의 항염증능이 백서의 LPS로 유발된 류마티스성 관절염에 미치는 영향

  • Lim, Dae-Jung (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Cho, Jae-Yong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Woong-Chae (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Park, In-Shik (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Kim, Kap-Sung (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University) ;
  • Kim, Gyeong-Ho (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Dongguk University)
  • 임대정 (동국대학교 한의과대학 침구학교실) ;
  • 조재용 (동국대학교 한의과대학 침구학교실) ;
  • 정웅채 (동국대학교 한의과대학 침구학교실) ;
  • 박인식 (동국대학교 한의과대학 침구학교실) ;
  • 김갑성 (동국대학교 한의과대학 침구학교실) ;
  • 김경호 (동국대학교 한의과대학 침구학교실)
  • Published : 2008.06.20
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Abstract

Objectives : This study is to evaluate Effect of Hong Hua Za acupuncture anti-inflammatory on rheumatoid arthritis that caused by Lipopolysaccharide in mouse. Methods : Hong Hua Za(Carthami Tinctorii Fructus) acupuncture(HA) was prepared and tested for therapeutic potential of rheumatoid arthritis, by measuring the inhibition of inducible nitric oxide synthase (iNOS) expression, nitric oxide(NO) production in vitro experiment, by measuring Tumpr Necrosis Factor-$\alpha$(TNF-$\alpha$) & Nuclear Factor kappa B(NF-$\kappa$B) p65 activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Results : HA showed therapeutic effects on Lipopolysaccharide(LPS)-induced rheumatoid arthritis. HA inhibited iNOS mRNA and NO in RAW264.7cell of LPS-induced rheumatoid arthritis in a dose dependent manner. HA also showed significant inhibition of TNF-$\alpha$ & NF-$\kappa$B p65, activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Conclusions : These results suggest that HA has an therapeutic effects on LPS induced-rheumatoid arthritis by inhibiting TNF-$\alpha$ activation.

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