The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Neuroprotective Effect of the Roots of Polygonum Cuspidatum on Transient Focal Cerebral Ischemia in Rats

호장근의 일시적 국소뇌허혈 흰쥐 모델에 대한 신경보호효과

  • Kim, Jin-Mo (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Cha, Dong-Suk (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Jeon, So-Ra (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Jeon, Hoon (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Lim, Jong-Pil (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Choi, Hoon (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Lee, Ki-Jin (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Kang, Min-Seok (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Na, Ho-Jeong (Dept. of Herbal Pharmacology, College of pharmacy, Woosuk University) ;
  • Kim, Mi-Yeon (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Korea Institutue of Science and Technology of East Medicine, NeuMed Co. Ltd) ;
  • Leem, Kang-Hyun (Dept. of Herbal Pharmacology. College of Oriental Medicine, Semyung University) ;
  • Kim, Ho-Cheol (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University, Korea Institutue of Science and Technology of East Medicine, NeuMed Co. Ltd) ;
  • Bu, Young-Min (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
  • 김진모 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 차동석 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 전소라 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 전훈 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 임종필 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 최훈 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 이기진 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 강민석 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 나호정 (우석대학교 약학대학 한약학과 본초학교실) ;
  • 김미연 (경희대학교 한의과대학 본초학교실, 뉴메드 한의과학기술연구소) ;
  • 임강현 (세명대학교 한의과대학 본초학교실) ;
  • 김호철 (경희대학교 한의과대학 본초학교실, 뉴메드 한의과학기술연구소) ;
  • 부영민 (경희대학교 한의과대학 본초학교실)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of the present study was to development of neuroprotective antioxidant agents. For the purpose, we investigated the neuroprotective effect of anti oxidant herb, the root of Polygonum cuspidatum on transient focal cerebral ischemia in rats. Methods : The roots of Polygonum cuspidatum were extracted by 85% MeOH (PCE). Radical scavenging effects were investigated using DPPH assay and TBARs (Thiobarbituric acid reaction substance) assay in brian homogenates. Neuroprotective effect was investigated using transient focal cerebral ischemia rat model (2 h of ischemia, 22 h of reperfusion) by behavioral test and measurement of brain damage using 2, 3, 5-triphenyltetrazolium chloride staining. Results : PCE showed potent and dose dependent radical scavenging effects in DPPH and TBARs assay. Oral administration of PCE reduced brain infarct volume by 29.7% and improved the sensory motor functional deficit by 29% compared with vehicle treated group. Conclusions : PCE showed radical scavenging effects and neuroprotective effect on stroke rat model. Therefore, Polygonum cuspidatum could be a candidate for the development of neuroprotective-antioxidant agents.

Keywords