The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Herbal-cheonggukjang on Serum Composition and Urine in Rats

생약초 청국장이 흰쥐의 혈액성분 및 뇨에 미치는 영향

  • Kim, Hyung-Woo (Research Center of Industrial Accelerators) ;
  • Cho, Su-Jin (College of Medicine, Korea University) ;
  • Kim, Bu-Yeo (Korea Institute of Oriental Medicine) ;
  • Jung, Sun (College of Korean Medicine, Dongshin University) ;
  • Park, Jung-Suk (Department of Complementary Alternative Therapy, Kwang-ju Womens University) ;
  • Lee, Sook-Young (Research Center for Proteineous Materials, Chosun University) ;
  • Cho, Su-In (School of Oriental Medicine, Pusan National University)
  • 김형우 (산업용가속기이용 생물연구센터) ;
  • 조수진 (고려대학교 의과대학) ;
  • 김부여 (한국한의학연구원) ;
  • 정선 (동신대학교 한의과대학) ;
  • 박정숙 (광주여자대학교 대체요법학과) ;
  • 이숙영 (조선대학교 단백질소재 연구센터) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Published : 2008.06.30
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Abstract

Objectives : Cheonggukjang(natto) is known to have anti-hyperlipidemic action in our previous study. This study was designed to investigate the safety of Prototype-cheonggukjang (PC, Herbal-natto). Methods : We investigated the effects of PC on changes in body weights, food uptake, water uptake, levels of AST/ALT, levels of BUN/creatinine and electrolytes in serum from normal mice. PC is made by cheonggukjang added Codonopsis Lanceolata, Houttuynia cordata and Lentinus edodes in indicated concetrations. Results : In this experiment, PC group showed equal levels of body weights, urine volume compared to non-treated control group. Oral administration of PC did not affect food and water uptake too. Levels of AST/ALT, which are markers of liver function, were not changed by administration of PC. In addition, levels of BUN/creatinine, which are markers of renal function, were not affected by PC too. Finally electrolytes in serum were not affected by PC. Conclusions : These results imply that oral administration of PC is safe in the framework of liver and renal function, and electrolytes in serum.

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