The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)
- Volume 22 Issue 2
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- Pages.81-114
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- 2008
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- 1226-8038(pISSN)
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- 2287-9463(eISSN)
Effect of Jeseupwiryeongtang-gagam on Atopic Dermatitis-like Skin NC/Nga Mouse Induced by Dermatophagoides Farinae Crude Extract
제습위령탕가감이 집 먼지 진드기 추출물로 유도된 NC/Nga mouse의 아토피 피부염에 미치는 영향
- Na, Dong-Gyu (Department of Pediatrics, College of Oriental Medicine, Daejeon University) ;
- Han, Jae-Kyung (Department of Pediatrics, College of Oriental Medicine, Daejeon University) ;
- Kim, Yun-Hee (Department of Pediatrics, College of Oriental Medicine, Daejeon University)
- Published : 2008.08.31
Abstract
Objectives : The purpose of this study is to investigate the effect of Jeseupwiryeongtang-gagam(JWTG) on atopic dermatitis by in vivo experiment using NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the atopic dermatitis of human. Methods : To investigate the effect of JWTG on AD, we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs), splenocytes, draining lymph node(DLN) and performed skin histology in ears and dorsal skin of atopic dermatitis-like skin NC/Nga mouse in vivo. Results and Conclusions : In vivo, clinical skin severity score were significantly lower in JWTG group than control group. IgE, IL-6,