The Korea Journal of Herbology (대한본초학회지)
- Volume 23 Issue 3
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- Pages.73-83
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Chloroform Fraction of Zingiberis Rhizoma Recens Modulates the Production of Inflammatory Mediators in LPS-stimulated BV2 Microglial Cells
생강 클로로포름 분획의 활성화된 뇌신경교세포(腦神經膠細胞)에서 염증반응 억제효과
- Seo, Un-Kyo (Department of Internal Medicine, Dongguk University Bundang Oriental Hospital) ;
- Jung, Hyo-Won (Department of Herbology, College of Oriental Medicine Dongguk University) ;
- Park, Yong-Ki (Department of Herbology, College of Oriental Medicine Dongguk University, Oriental Medicine Drug R&D Center, College of Oriental Medicine, Dongguk University)
- Published : 2008.09.30
Abstract
Objectives : The root of Zingiber officinale ROSC. (Zingiberis Rhizoma Recens; Ginger) has been widely used as one of folk remedies and food materials in many traditional preparations. Ginger is known as an effective appetite enhancer and anti-inflammatory agent. This study was performed to investigate the effect of ginger chloroform fraction (GCF) in microglia which play a central role on brain inflammation in neurodegenerative diseases. Methods : Dried ginger was extracted with 80% methanol, and then fractionated with chloroform. BV2 mouse microglial cells were cultured with different concentrations of GCF and then stimulated with LPS (1
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