생약학회지 (Korean Journal of Pharmacognosy)

  • 제39권3호
  • /
  • Pages.223-227
  • /
  • 2008
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

한국약용식물의 최종당화산물 생성저해활성 검색 (II)

Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (II)

  • 이윤미 (한국한의학연구원 한약제제연구부) ;
  • 김영숙 (한국한의학연구원 한약제제연구부) ;
  • 김종민 (한국한의학연구원 한약제제연구부) ;
  • 장대식 (한국한의학연구원 한약제제연구부) ;
  • 김주환 (대전대학교 생명과학부) ;
  • 유정림 (한국한의학연구원 한약제제연구부) ;
  • 김진숙 (한국한의학연구원 한약제제연구부)
  • Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Young-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Joo-Hwan (Department of Life Science, Daejeon University) ;
  • Yoo, Jeong-Lim (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
  • 발행 : 2008.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Advanced glycation end products (AGEs) contribute to the progression of micro and macrovsacular complication of diabetes and therefore present a promising target for therapeutic agents. In this study, 40 Korean herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 21 herbal medicines $(IC_{50}<50{\mu}g/ml)$ exhibited an inhibitory activity against AGEs formation compared with anminoguanidine $(IC_{50}=72.12{\mu}g/ml)$. Particularly, 7 herbal medicines, Actinidia arguta (root and stem), Crataegus pinnatifida (twig), Camellia japonica (whole), Kalopanax pictus (bark), Lagerstroemia indica (leaf-stem), Reynoutria sachalinensis (root) showed more potent inhibitory activity (approximately 3-10 fold) than the positive control aminoguanidine.

키워드

참고문헌

  1. Ahmed N. (2005) Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res. Clin. Pract. 67: 3-21 https://doi.org/10.1016/j.diabres.2004.09.004
  2. Larkins RG, Dunlop ME. (1992) The link between hyperglycaemia and diabetic nephropathy. Diabetologia 35: 499-504 https://doi.org/10.1007/BF00400475
  3. Brownlee M. (2005) The Pathobiology of diabetic complications: A unifying mechanism. Diabetes 54: 1615-1625 https://doi.org/10.2337/diabetes.54.6.1615
  4. Huebschmann A.G., Vlassara H, Regensteiner JG, Reusch J.(2007) Diabetes and advanced glycoxidation end products. Annual review of diabetes 51-63
  5. Rahbar, S. and Figarola, J.L. (2003) Novel inhibitors of advenced glycation endproducts. Arch. Biochem. Biophys. 419: 63-79 https://doi.org/10.1016/j.abb.2003.08.009
  6. Wilkinson-Berka JL, Kelly DJ, Koerner SM, Jaworski K, Davis B, Thallas V, Cooper ME. (2002) ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. Diabetes 51: 3283-9 https://doi.org/10.2337/diabetes.51.11.3283
  7. Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J. (2006) Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). Am J Nephrol. 26: 430-6 https://doi.org/10.1159/000095786
  8. Yang S, Litchfield JE, Baynes JW. (2003) AGE-breakers cleave model compounds, but do not break Maillard crosslinks in skin and tail collagen from diabetic rats. Arch Biochem. Biophys. 412: 42-6 https://doi.org/10.1016/S0003-9861(03)00015-8
  9. Jang DS, Lee GY, Kim YS, Lee YM, Kim CS, Yoo JL, Kim JS.(2007) Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Biol. Pharm. Bull. 30: 2207-10 https://doi.org/10.1248/bpb.30.2207
  10. Kim YS, Lee YM, Kim C-S, Sohn EJ, Jang DS, and Kim JS (2006) Inhibitory effect of KIOM, a new herbal prescription, on AGEs formation and expression of type IV collagen and TGF-$\beta$1 in STZ-induced diabetic rats. Kor. J. Pharmacogn. 37: 103-109
  11. Kim CS, Sohn EJ, Kim YS, Jung DH, Jang DS, Lee YM, Kim DH, Kim JS (2007) Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. J Ethnopharmacol. 111(2): 240-247 https://doi.org/10.1016/j.jep.2006.11.023
  12. Jang DS, Lee YM, Kim YS, and Kim JS (2006) Screening of Korean traditional herbal medicines with inhibitory activity on advanced glycation end products (AGEs) formation. Kor. J. Pharmacogn. 37: 48-52
  13. Vinson, J.A. and Howard , T.B. (1996) Inhibition of protein glycation and advanced glycation endproducts by ascorbic acid and other vitamins and nutrients. J. Nutr. Biochem. 7:659-663 https://doi.org/10.1016/S0955-2863(96)00128-3
  14. Webby RF. (1991) A flavonol triglycoside from Actinida arguta var. giraldii. Phytochemistry. 30: 2443-2444 https://doi.org/10.1016/0031-9422(91)83680-J
  15. Lim H-W, Kang SJ, Park M, Yoon JH, Han BH, Choi S-E, Lee M (2006) Antioxidative and nitric oxide production inhibitory activities of pheolic compounds from fruits of Actinidia arguta. Nat. Prod. Sci. 12: 221-225
  16. Jang DS, Lee GY, Kim J, Lee YM, Kim JM, Kim YS, Kim JS. (2008) A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta. Arch. Pharm. Res. 31: 666-670 https://doi.org/10.1007/s12272-001-1210-9
  17. Itokawa H, Nakajima H, Ikuta A, Iitaka Y. (1981) Two teiterpenes from the flowers of Camellia japonica. Phytochemistry. 20: 2539 https://doi.org/10.1016/0031-9422(81)83089-0
  18. Namba T, Tsunezuka M, Takehana Y, Nunome S, Takeda K, Shu YW, Kakiuchi S, Takigi S and Hattori M (1984) Studies on dental caries prevention by traditional Chinese medicines. IV. Screening of crude drugs for anti-plaque action and effects on Artemisia capollaris spikes on adgerence of Streptociccus mutans to smooth surfaces and synthesis of glucan, Shoyakugaku Zasshi. 38: 263-264
  19. Kim SM, Hwang EJ, Pyo B-S, Lee S-Y (2004) Antioxidant and antimicrobial activities of the extracts from native Camellia japonica in Kore. Korean J. Plant Res. 17: 314-322
  20. Kao ES, Wang CJ, Lin WL, Yin YF, Wang CP, Tseng TH (2005) Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo. J. Agric. Food. Chem. 53: 430-436 https://doi.org/10.1021/jf040231f
  21. Park H, Kim MS, Jeon BH, Kim TK, Kim YM, Ahnn J, Kwon DY, Takaya Y, Wataya Y, Kim HS. (2003) Antimalarial activity of herbal extracts used in traditional medicine in Korea. Biol Pharm. Bull. 26: 1623-1624 https://doi.org/10.1248/bpb.26.1623
  22. Min SK, Park YK, Park JH, Jin SH, Kim KW (2004) Screening of Antibacterial Activity from hot Water Extracts of Indigenous Plants J. Life Sci. 14: 956-952
  23. Zhang X, Thuong PT, Jin W, Su ND, Sok DE, Bae K, Kang SS (2005) Antioxidant activity of anthraquinones and flavonoids from flower of Reynoutria sachalinensis. Arch. Pharm. Res 28: 22-7 https://doi.org/10.1007/BF02975130
  24. Choi SY, Jung SH, Lee HS, Park KW, Yun BS, Lee KW. (2008) Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract. Phytother. Res 22: 323-329 https://doi.org/10.1002/ptr.2316
  25. Jang DS, Kim JM, Lee YM, Kim YS, Kim JH, Kim JS. (2006) Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata. Chem. Pharm .Bull . 54: 1315-1317 https://doi.org/10.1248/cpb.54.1315
  26. Kim JM, Lee YM, Lee GY, Jang DS, Bae KH, Kim JS. (2006) Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs). Arch. Pharm. Res. 29: 821-825 https://doi.org/10.1007/BF02973900