대한한의학회지 (The Journal of Korean Medicine)
- 제29권4호
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- Pages.68-82
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- 2008
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
활혈막성방(活血膜性方)이 Cationized Bovine Serum Albumin투여로 유발된 Mouse의 Membranous Nephropathy에 미치는 영향
The Effects of Hwalhyulmaksung-bang (Huoxiemoxing-fang) on Membranous Nephropathy Induced by Cationic Bovine Serum Albumin in Mouse Model
- Kim, Doo-Hee (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
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Cho, Chung-Sik
(Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
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Kim, Cheol-Jung
(Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
- 발행 : 2008.09.30
초록
Objective: The purpose of our study was to show the effects of Hwalhyulmaksung-bang (Huoxiemoxing-fang, HHMSB) treatment on cBSA-induced in MN Mouse Model. Methods: We divided the 20 mice into 4 groups. One group, named NR, was not treated. The second group, named CT, was treated with cBSA (7mg/kg i.p) only. The third group, named HH-250, was treated with cBSA (7mg/kg i.p) and HHMSB extract (250mg/kg, p.o). The fourth group, named HH-500, was treated with cBSA (7mg/kg i.p) and HHMSB extract (500mg/kg, p.o). 4 weeks after cBSA, proteinuria, serum albumin, total cholesterol, serum creatinine, BUN, total cell number of spleen and kidney of all groups were measured. CD3e+/CD19+ and CD4+/CD8 cells ratio of peripheral blood, kidney and spleen of all groups were analyzed.
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