Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Angio-invasive Pulmonary Mucormycosis with Uncontrolled Diabetes Mellitus

당뇨 환자에서 진단된 대량 객혈을 보인 폐 모균증 1예

  • Cho, Yu Ji (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University College of Medicine) ;
  • Kang, Myoung Hee (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University College of Medicine) ;
  • Kim, Hyeon Sik (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University College of Medicine) ;
  • Jeong, Yi Yeong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University College of Medicine) ;
  • Jang, In-Seok (Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine) ;
  • Kim, Ho Cheol (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University College of Medicine) ;
  • Hwang, Young Sil (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University College of Medicine) ;
  • Lee, Jong Deog (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University College of Medicine)
  • 조유지 (경상대학교 의과대학 전문대학원 내과학교실) ;
  • 강명희 (경상대학교 의과대학 전문대학원 내과학교실) ;
  • 김현식 (경상대학교 의과대학 전문대학원 내과학교실) ;
  • 정이영 (경상대학교 의과대학 전문대학원 내과학교실) ;
  • 장인석 (경상대학교 의과대학 전문대학원 흉부외과학교실) ;
  • 김호철 (경상대학교 의과대학 전문대학원 내과학교실) ;
  • 황영실 (경상대학교 의과대학 전문대학원 내과학교실) ;
  • 이종덕 (경상대학교 의과대학 전문대학원 내과학교실)
  • Received : 2008.05.02
  • Accepted : 2008.06.02
  • Published : 2008.06.30
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Abstract

Pulmonary mucormycosis is an uncommon, serious opportunistic infection caused by fungi belonging to the order Mucorales and it occurs exclusively in debilitated or immuno-compromised hosts. It is known that the fungi can invade the blood vessels and cause serious ischemic necrosis and bleeding5. We experienced a fatal case of pulmonary mucormycosis in a diabetic 75-year-old man who developed a progressive necrotizing lesion despite administering proper and prompt medical and surgical treatment. We report here on this case along with a review of the relevant medical literature.

저자들은 잘 조절되지 않는 당뇨병을 가진 75세 환자에서 혈관을 침범한 폐 모균증으로 인해 항진균제와 수술적 치료를 시행하였으나 진행되는 다발성 괴사로 인한 객혈로 사망한 폐 모균증 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

Keywords

References

  1. Sugar AM. Mucormycosis. Clin Infect Dis 1992;14: S126-9 https://doi.org/10.1093/clinids/14.Supplement_1.S126
  2. Rinaldi MG. Zygomycosis. Infect Dis Clin North Am 1989;3:19-41
  3. Virally ML, Riveline JP, Virally J, Chevojon P, Regnard JF, Belmekki A, et al. Pulmonay mucormycosis in a diabetic patient with HIV. Diabetes Care 2002;25:2105 https://doi.org/10.2337/diacare.25.11.2105
  4. Joshi N, Caputo GM, Weitekamp MR, Karchmer AW. Infections in patients with diabetes mellitus. N Engl J Med 1999;341:1906-12 https://doi.org/10.1056/NEJM199912163412507
  5. Davies SF, Knox KS, Sarosi GA. Chapter 34. Fungal infection. In: Mason RJ, Broaddus VC, Murray JF, Nadel JA, editors. Murray and Nadel's textbook of respiratory medicine. 4th ed. Philadelphia: Sanders Elsevier Inc; 2005. p. 1073-4
  6. Murray HW. Pulmonary mucormycosis with massive fatal hemoptysis. Chest 1975;68:65-8 https://doi.org/10.1378/chest.68.1.65
  7. Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev 2000;13:236-301 https://doi.org/10.1128/CMR.13.2.236-301.2000
  8. Chang MS, Woo JH. Opportunistic fungal infection. Hanyang Med Rev 2006;26:20-33
  9. McAdams HP, Rosado de Christenson M, Strollo DC, Patz EF Jr. Pulmonary mucormycosis: radiologic findings in 32 cases. AJR Am J Roentgenol 1997;168: 1541-8 https://doi.org/10.2214/ajr.168.6.9168721