동국한의학연구소논문집 (The Journal of Dong Guk Oriental Medicine)

  • 제11권
  • /
  • Pages.58-65
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  • 2008
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  • 1226-556X(pISSN)
동국대학교 한의학연구소 (Research Institute of Oriental Medicine)
권호 표지

BHT-C의 허혈성 뇌졸중 동물에서의 뇌부종 억제효과

Effect of BHT-C extract on the infarction in cerebral ischemic rats

  • 김성윤 (동국대학교 한의과대학 본초학교실) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Kim, Sung-Yoon (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
  • 발행 : 2008.12.30
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초록

Objectives : BHT has been commonly used to treatment of brain disorders in Oriental clinic in Korea. The purpose of this study was to determine the inhibitory effect of modified BHT-C extract on the transient forcal cerebral ischemia in rats. Method : We prepared ischemic rats by the transient middle cerebral artery occlution(MCAO; 90 min occlusion and 144 h reperfusion) in rat brains. BHT-C extract (100 and 200 mg/kg, i.p.) was administered every day after the onset of MCAO until 6 day. Result : BHT-C extract increased survival rate of ischemic rats compared with vehicle-treated rats. BHT-C extract treated rats (100 and 200 mg/kg) were shown a significant reduction in infarct volume compared with vehicle-treated rats. Conclusions : These results suggest that BHT-C extract may contribute to its protective effects in brain ischemia through the reduction of brain infarction.

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