한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제25권3호
  • /
  • Pages.202-206
  • /
  • 2008
  • /
  • 1598-298X(pISSN)
  • /
  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Topical Application of 0.1% Tacrolimus Ointment for Treatment of Sinus Refractory Pododermatitis Secondary to Atopy in a Dog

  • Kim, Ha-Jung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Yoo, Jong-Hyun (BK21 program of Integrative network systems for veterinarians in basic science, industrial animals and preventive medicines, Konkuk University) ;
  • Park, Chul (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 발행 : 2008.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

An 8-year-old, castrated male Shih-tzu was referred due to relapsing pododermatitis and generalized pruritus. On physical examination, right forepaw showed swelling and serosanguinous exudates from sinus tract on dorsal paw. There were no remarkable findings on complete blood count (CBC), serum chemistry, and radiologic examination. On cytological examination of exudates from sinus tract, phagocyted bacteria and numerous degenerative neutrophils were noted. Results of deep skin scraping and plucking hair examination were unremarkable. Skin biopsy was performed and ruled out other skin diseases. Histopathology showed epidermal hyperplasia and diffuse mononuclear cell inflammation in dermal layer. Moreover, pyogranulomatous inflammation was demonstrated in subcutaneous layer. This case was clinically diagnosed as pododermatitis secondary to atopic dermatitis (AD). Clinical signs of pododermatitis were gradually improved following topical application of tacrolimus 0.1% ointment. This case report describes that tacrolimus ointment can be applicable for the treatment of refractory pododermatitis.

키워드

참고문헌

  1. Anderson RK. Canine pododermatitis. Compend Cont Educat Pract Vet 1980; 11: 361-371
  2. Bensignor E, Olivry T. Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trial. Vet Dermatol 2005; 16: 52-60 https://doi.org/10.1111/j.1365-3164.2005.00419.x
  3. Breathnach RM, Baker KP, Quinn PJ, Mcgeady TA, Aherne CM, Jones BR. Clinical, immunological and histopathological findings in a subpopulation of dogs with pododermatitis. Vet Dermatol 2005; 16: 364-372 https://doi.org/10.1111/j.1365-3164.2005.00471.x
  4. Breathnach RM, Fanning S, Mulcahy G, Bassett HF, Jones BR. A study of dendritic cell and MHC class expression in dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis. Vet J 2007 (In Press)
  5. Ellis C, Luger T, Abeck D, Allen R, Graham-Brown RA, De Prost Y, Eichenfield LF, Ferrandiz C, Giannetti A, Hanifin J, Koo JY, Leung D, Lynde C, Ring J, Ruiz-Maldonado R, Saurat JH. International Consensus Conference on Atopic dermatitis II (ICCAD II): clinical update and current treatment strategies. Br J Dermatol 2003; 148: S3-S10 https://doi.org/10.1046/j.1365-2133.148.s63.1.x
  6. Gewirtz AT, Sitaraman SV. Tacrolimus Fujisawa. Curr Opin in Investig Drugs 2002; 3: 1307-1311
  7. Gupta AK, Adamiak A, Chow M. Tacrolimus: a review of its use for the management of dermatoses. J Eur Acad Dermatol Venereol 2002; 16: 100-114 https://doi.org/10.1046/j.1468-3083.2002.00380.x
  8. Marsella R, Nicklin CF. Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. Vet Dermatol 2002; 13: 203-210 https://doi.org/10.1046/j.1365-3164.2002.00299.x
  9. Marsella R, Nicklin CF, Saglio S, Lopez J. Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (Protopic(R)) in canine atopic dermatitis: a randomized, doubleblinded, placebo-controlled, cross-over study. Vet Dermatol 2004; 15: 294-303 https://doi.org/10.1111/j.1365-3164.2004.00397.x
  10. Mason IS. Canine pyoderma. J Small Anim Pract 1991; 32: 381-386 https://doi.org/10.1111/j.1748-5827.1991.tb00960.x
  11. Medleau L, Hnilica KA. Bacterial Pododermatitis. In: Small animal dermatology: A color of atlas and therapeutic guide, 2nd edn. Philadelphia: W.B. Saunders Company. 2006: 41
  12. Muller GH. Skin diseases of the Chinese Shar-Pei. Vet Clin North Am Small Anim Pract 1990; 20: 1655-1670 https://doi.org/10.1016/S0195-5616(90)50166-7
  13. Nghiem P, Pearson G, Langley RG. Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J Am Acad Dermatol 2002; 46: 228-241 https://doi.org/10.1067/mjd.2002.120942
  14. Rosser EJ Jr. German shepherd dog pyoderma: a prospective study of 12 dogs. J Am Anim Hosp Assoc 1997; 33: 355-363 https://doi.org/10.5326/15473317-33-4-355
  15. Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y, Amaya T, Goto T. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system (Comparison with steroids). Int Immunopharmacol 2001; 1: 1219-1226 https://doi.org/10.1016/S1567-5769(01)00059-5
  16. cott DW, Miller Jr. WH, Griffin CE. Bacterial skin disease. In: Small Animal Dermatology, 6th ed. Philadelphia: W.B. Saunders Company. 2001: 274-335
  17. Soter NA, Fleischer AB Jr, Webster GF, Monroe E, Lawrence I. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safety. J Am Acad Dermatol 2001; 44: S39-S46 https://doi.org/10.1067/mjd.2001.109817
  18. Trautmann A, Akdis M, Schmid-Grendelmeier P, Disch R, Brocker EB, Blaser K, Akdis CA. Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis. J Allergy Clin Immunol 2001; 107: 345-352 https://doi.org/10.1067/mai.2001.112600
  19. van den Berg AP, van Son WJ, Haagsma EB, The TH, Slooff MJ, de Leij LM. Prediction of the inhibition of IL-2 production by calcineurin inhibitors. Transplantation Proceedings 2001; 33: 1076-1077 https://doi.org/10.1016/S0041-1345(00)02422-2
  20. White S. Pododermatitis. In: Locke PH, Harvey RG, Mason IS eds. Manual of Small Animal Dermatology. Gloucestershire: British Small Animal Veterinary Assocoation Publications. 1993: 146-156
  21. Willemse A. Atopic skin disease: a review and a. reconsideration of diagnostic criteria. J Small Anim Prac 1986; 27: 771-778 https://doi.org/10.1111/j.1748-5827.1986.tb02119.x
  22. Yetman RJ, Parks D. Diagnosis and management of atopic dermatitis. J Pediatr Healthc 2002; 16: 143-145 https://doi.org/10.1016/S0891-5245(02)02281-2