Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Effects of Hominis Placenta Herbal-Acupuncture Solution on the Alzheimer's Disease Model Induced by ${\beta}A$

자하차(紫河車) 약침(藥鍼)이 ${\beta}A$로 유도(誘導)된 Alzheimer's Disease 병태(病態) 모델에 미치는 영향(影響)

  • Lee, Byung-Hun (Dept. of Neuropsychiatry, College of Oriental Medicine, Daegu Hanny University) ;
  • Park, Sun-Young (Dept. of Neuropsychiatry, College of Oriental Medicine, Daegu Hanny University) ;
  • Choi, Cheol-Hong (Dept. of Neuropsychiatry, College of Oriental Medicine, Daegu Hanny University) ;
  • Lee, Eun-Kyung (Dept. of Neuropsychiatry, College of Oriental Medicine, Daegu Hanny University) ;
  • Chung, Dae-Kyoo (Dept. of Neuropsychiatry, College of Oriental Medicine, Daegu Hanny University)
  • 이병훈 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 박선영 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 최철홍 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 이은경 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 정대규 (대구한의대학교 한의과대학 신경정신과 교실)
  • Published : 2008.07.30
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Abstract

Objective: Hominis Placenta is used in many cure, mainly treats a weak, chronic disease, especially senile. This research investigates the effect of the Hominis Placenta Herbal-Acupuncture Solution on Alzheimer's disease. Method: The effects of the Hominis Placenta Herbal-Acupuncture Solution on (1) $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, and CD68/CD11b (2) the behavior (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with 13A were investigated. Results: 1. For the Hominis Placenta Herbal-Acupuncture Solution group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}$ A in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 2. The Hominis Placenta Herbal-Acupuncture Solution group suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by ${\beta}A$. 3. The Hominis Placenta Herbal Acupuncture Solution group reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. 4. The Hominis Placenta Herbal-Acupuncture Solution group reduced the Tau protein, GFAP protein, and presenilin1/2 protein, beta-secretase protein, (immunohistochemistry) of hippocampus in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusion: These results suggest that the Hominis Placenta Herbal-Acupuncture Solution group may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Hominis Placenta Herbal-Acupuncture Solution for Alzheimer's disease is suggested for future research.

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