The Korean Journal of Nuclear Medicine Technology (핵의학기술)

The Korean Society of Nuclear Medicine Technology (대한핵의학기술학회)
권호 표지

Simple and Highly Efficient Synthesis of [$^{11}C$]methionine Using Solid-Phase Extraction Method

고정상 추출법을 이용한 효율적인 [$^{11}C$]methionine의 합성

  • Lim, Sung-Jae (Department of Nuclear Medicine, Asan Medical Center) ;
  • Moon, Woo-Yeon (Department of Nuclear Medicine, Asan Medical Center) ;
  • Choi, Jae-Chil (Department of Nuclear Medicine, Asan Medical Center) ;
  • Cho, Shee-Man (Department of Nuclear Medicine, Asan Medical Center) ;
  • Oh, Seung-Jun (Department of Nuclear Medicine, Asan Medical Center)
  • Received : 2008.06.16
  • Accepted : 2008.09.01
  • Published : 2008.10.25
Download PDF
⟨ Previous Next ⟩

Abstract

We developed simple and highly efficient synthesis method for [$^{11}C$]methionine using solid-phase extraction method. For synthesis, we used C18 cartridge. [$^{11}C$]methionine was synthesized on C18 cartridge according to the solid-phase [$^{11}C$]methylation of precursor L-homocysteine thiolactone hydrochloride. The radiochemical yields of [$^{11}C$]methionine was $48.9{\pm}7.93%$ decay corrected (results of 30 syntheses, mean$\pm$SD), with average production higher than 180 mCi. This procedure showed high yield and simple synthesis of [$^{11}C$]methionine.

Keywords