Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Ovariectomy and Calcium Intake on Lipid Profile and Antioxidant Capacities in Rats

난소절제와 칼슘 섭취수준이 흰쥐의 지질패턴과 항산화능에 미치는 영향

  • Choi, Mi-Kyeong (Department of Human Nutrition & Food Science, Chungwoon University) ;
  • Kang, Myung-Hwa (Department of Food and Nutrition, Hoseo University) ;
  • Kim, Mi-Hyun (Department of Food and Nutrition, Kangwon National University)
  • 최미경 (청운대학교 식품영양학과) ;
  • 강명화 (호서대학교 식품영양학과) ;
  • 김미현 (강원대학교 식품영양학과)
  • Published : 2008.06.30
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Abstract

The purpose of this research was to investigate the effect of the calcium intake on lipid profile and antioxidant capacities in ovariectomized (OVX) rats. Rats were divided into 3 groups and fed diet with different levels of calcium (low 0.1%, adequate 0.5%, high 1.5%) for 4 weeks. The half of rats in each group was ovariectomized and the others were sham-operated. And rats were fed same diets for 8 weeks after operation. Feed intake and weight gain were significantly higher in OVX group than those in sham-operated. Serum HDL-cholesterol was the highest in high-calcium group of OVX. Hepatic triglyceride of low-calcium group in sham-operated was the highest, while that of highcalcium group in OVX was the highest. Hepatic activities of glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px), and catalase were significantly decreased by increasement of calcium intake. Hepatic TBARS level was the lowest in high-calcium group of OVX. And hepatic level of TBARS induced by AAPH was significantly decreased by increasement of calcium intake. These results may indicate that the high calcium intake have the potential role to improve lipid profiles and antioxidant capacities in OVX rats.

Keywords

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