Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

The Effect of Herbal Formulation KH-305 Mainly consisted of Rubus Coreanus on Benign Prostatic Hyperplasia-Induced Rat

전립선 비대증 유발 백서에서 복분자를 주성분으로 한 생약제제 KH-305가 미치는 영향

  • Kim, Sung-Dae (From the Department of Urology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Byung-Hee (From the Department of Urology, College of Medicine, The Catholic University of Korea) ;
  • Sohn, Dong-Wan (From the Department of Urology, College of Medicine, The Catholic University of Korea) ;
  • Cho, Yong-Hyun (From the Department of Urology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Seung-Min (Korea Medical Science Institute) ;
  • Kim, Jeong-Ok (Korea Medical Science Institute) ;
  • Kim, Sae-Woong (From the Department of Urology, College of Medicine, The Catholic University of Korea)
  • 김성대 (가톨릭대학교 의과대학 비뇨기과학교실) ;
  • 이병희 (가톨릭대학교 의과대학 비뇨기과학교실) ;
  • 손동완 (가톨릭대학교 의과대학 비뇨기과학교실) ;
  • 조용현 (가톨릭대학교 의과대학 비뇨기과학교실) ;
  • 이승민 ((주)KMSI 부설 한국의과학연구소) ;
  • 김정옥 ((주)KMSI 부설 한국의과학연구소) ;
  • 김세웅 (가톨릭대학교 의과대학 비뇨기과학교실)
  • Published : 2008.06.30
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Abstract

Benign prostatic hyperplasia (BPH) is one of the common diseases in elderly men. Recently, the old-aged population has increased, with the interest in the clinical importance of BPH ever growing. This study is designed to investigate the effects of KH-305 on BPH induced rat. The herb formulation KH-305 is consisted of Rubus coreanus, Cornus officinalis and Cuscuta chinensis. An experimental prostatic hyperplasia was induced in male rats by the administration of testosterone propionate, 3 mg/kg SC, for 2 months. The rats were divided into 3 experimental groups: the control, BPH-induced, oral KH-305 ingestion group. After 2 months, the prostates were removed, and analyzed for their prostatic weight and histological examination. The prostate weights were measured in each group, and found to be 820${\pm}$38mg, 3140${\pm}$26mg, 1880${\pm}$21mg in the control, BPH-induced, and oral KH-305 ingestion group, respectively. The BPH induced group showed statistically significant increases in their prostatic weights compared with control group(p<0.05) but oral KH-305 ingestion group showed more significant decreases than BPH-induced group statically(p<0.05). Histologically injected testosterone lead to prostatic hyperplasia in rats, but oral KH-305 ingestion decreased this change. These results suggest that KH-305 may be effective in treatment of BPH, and complementary medicine of BPH.

Keywords

References

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