Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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A Comparative Study for Effects of Chongmyungtang and Chocolate Mixed Chongmyungtang on Learning and Memory Impairment

총명탕과 초콜릿 첨가 총명탕의 학습 및 기억장애에 대한 효능 비교연구

  • Kim, Seong-Joon (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University) ;
  • Park, Won-Sang (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University) ;
  • Choi, Hyeon (Hamsoa Pharmaceutical Co.) ;
  • Kim, Bum-Hoi (Dept. of Anatomy & Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Shin, Jung-Won (Dept. of Anatomy & Neurobiology, School of Medicine, Washington University in St.) ;
  • Sohn, Young-Joo (Dept. of Gynecology, College of Oriental Medicine, Sangji University) ;
  • Sohn, Nak-Won (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University) ;
  • Jung, Hyuk-Sang (Dept. of Anatomy & Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University)
  • 김성준 (경희대학교 동서의학대학원 신경과학 및 뇌질환) ;
  • 박원상 (경희대학교 동서의학대학원 신경과학 및 뇌질환) ;
  • 최현 ((주)함소아 제약) ;
  • 김범회 (경희대학교 한의과대학 해부학교실, 한의학연구소) ;
  • 신정원 (워싱턴대학교 의과대학 해부학 및 신경생물학교실) ;
  • 손영주 (상지대학교 한의과대학 부인과학교실) ;
  • 손낙원 (경희대학교 동서의학대학원 신경과학 및 뇌질환) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실, 한의학연구소)
  • Published : 2008.06.30
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Abstract

With tablets and powder, decoction has been a widely-used method of medicine formula. However, for these formulas have unique bitter tastes and flavors of herbal component materials as it is, the compliance of herbal medicine is severly decreased especially for female and younger patients. Consequently, expected treatment effects can't be acquired completely. If loathsome tastes and flavors of decoction were effectively reduced while pharmacological activity were kept intact, the compliance could be promoted Chong-Myung-Tang has been widely prescribed for student patients with memory This study shows that Chong-Myung-Tang+chocolate have no difference from Chong-Myung-Tang in terms of pharmacological activity. Sensory difference with net chocolate was also surved. In order to observe the difference of Chong-Myung-Tang+chocolate and Chong-Myung-Tang, memory impairment was induced by intraventricular injection of $A{\beta}_{25-35}$ peptides on mice and Chong-Myung-Tang and Chong-Myung-Tang+chocolate were administered orally for 14 days. In water maze task, improvement of learning ability during acquisition period and significant increase of memory score during retention period resulted from the treatment of Chong-Myung-Tang and Chong-Myung-Tang+chocolate with respect to the $A{\beta}-injected$ control animals. Furthermore, the $A{\beta}_{25-35}$ toxicity on the hippocampus was assessed with immunohistochemistry (Bax, TUNEL), and differences in antioxidant activity was observed through TBARS and DPPH test. We employed sensory tests using chocolate flavor, herb flavor, and bitter taste & hardness as standards to show sensory differences with net chocolate. In this study, it is demonstrated that Chong-Myung-Tang+chocolate do not disturb the pharmacological activity of Chong-Myung-Tang, and have no sensory difference with net chocolate. Chong-Myung-Tang+chocolate can be used to enhance the compliance remarkably and thought of as an effective, functional formula to maximize expected treatment.

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