Herbal Formula Science (대한한의학방제학회지)
- Volume 16 Issue 1
- /
- Pages.109-115
- /
- 2008
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- 1229-1218(pISSN)
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- 2288-5641(eISSN)
Micronucleus test of Sipjeondaebo-tang extract using the bone marrow cells in ICR mice
ICR 마우스 골수세포를 이용한 십전대보탕 소핵시험
-
Ma, Jin-Yeul
(Korea Institue of Oriental Medicine)
;
- Lee, Nam-Hun (Korea Institue of Oriental Medicine) ;
- Huang, Dae-Sun (Korea Institue of Oriental Medicine) ;
-
Ha, Hye-Kyung
(Korea Institue of Oriental Medicine)
;
- Yu, Young-Beob (Korea Institue of Oriental Medicine) ;
-
Shin, Hyun-Kyoo
(Korea Institue of Oriental Medicine)
-
마진열
(한국한의학연구원 한약제제연구부)
;
- 이남헌 (한국한의학연구원 한약제제연구부) ;
- 황대선 (한국한의학연구원 한약제제연구부) ;
-
하혜경
(한국한의학연구원 한약제제연구부)
;
- 유영법 (한국한의학연구원 한약제제연구부) ;
-
신현규
(한국한의학연구원 한약제제연구부)
- Published : 2008.06.30
Abstract
Objectives : This study was to assessment the toxicity of Sipjeondaebo-tang(Shiquan dabu-decoction) by micronucleus test. Methods : Sipjeondaebo-tang(Shiquan dabu-decoction) water-extract in vivo micronucleus test was performed using 7 weeks ICR mice. At 24 hours after with Sipjeondaebo-tang extract at the doses of 0, 500, 1000 and 2000 mg/kg/day by peritoneal route mice were sacrificed and bone marrow cells were prepared for smear slides. Results : As a result of counting the micronucleus polychromate erythrocyte of 2000 polychromate erythrocyte, all treatment groups did not show statistically significant increase than negative control group. and there was no clinical sign and body weight connected with injection of Sipjeondaebo-tang(Shiquan dabu-decoction) extract. Conclusions: It was concluded that Sipjeondaebo-tang extract did not induce micronucleus in the bone marrow cells of ICR mice
Keywords
- Sipjeondaebo-tang;
- Shiquan dabu-decoction;
- micronucleus;
- polychromate erythrocyte;
- bone marrow cells