Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Solubilization of Talniflumate in Microemulsion Systems

마이크로에멀젼을 이용한 탈니플루메이트의 가용화

  • Lee, Gye-Won (Laboratory Of Galenic Technology, Department of Pharmaceutical Engineering, Konyang University) ;
  • Cho, Young-Ho (Laboratory Of Galenic Technology, Department of Pharmaceutical Engineering, Konyang University) ;
  • Kim, Hak-Hyung (Laboratory Of Galenic Technology, Department of Pharmaceutical Engineering, Konyang University) ;
  • Kim, Sock-Young (Laboratory Of Galenic Technology, Department of Pharmaceutical Engineering, Konyang University) ;
  • Kim, Do-Kyun (Laboratory Of Galenic Technology, Department of Pharmaceutical Engineering, Konyang University) ;
  • Kim, Eun-Hea (Laboratory Of Galenic Technology, Department of Pharmaceutical Engineering, Konyang University)
  • 이계원 (건양대학교 제약공학과 제제개발실) ;
  • 조영호 (건양대학교 제약공학과 제제개발실) ;
  • 김학형 (건양대학교 제약공학과 제제개발실) ;
  • 김석영 (건양대학교 제약공학과 제제개발실) ;
  • 김도균 (건양대학교 제약공학과 제제개발실) ;
  • 김은혜 (건양대학교 제약공학과 제제개발실)
  • Published : 2008.06.20
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Abstract

Talniflumate is a nonsteroidal anti-inflammatory drug (NSAID), which has been used treat of rheumatoid diseases, is insoluble in water, therefore it has low bioavailability after oral administration. The purposes of this study were to prepare O/W or W/O microemulsions for solubilization of poorly water soluble drug, talniflumate and to formulate into other dosage form. For this purpose, we made O/W or W/O microemulsion with oil(soybean oil, IPM), surfactant (Cremophor $EL^{(R)}$, Tween 80) and water or propylene glycol and evaluated solubility of talniflumate. The microemulsion systems were very stable and showed transmittance above 95% without flocculation or aggregation. Especially, the solubility of talniflumate in the formulation B-1 containing 18% of isopropyl myristate and 71% of tween 80 was 10 times higher than that of other O/W microemulsions. The addition of propylene glycol and N-methylglutamine to the fomulation B-1 showed excellent capacity on the solubilization of talniflumate and the percentage was almost 2.0%. These results suggest that the microemulsion system may be promising for the solubility improvement of talniflumate.

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References

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