대한지역사회영양학회지 (Korean Journal of Community Nutrition)

대한지역사회영양학회 (The Korean Society of Community Nutrition)
권호 표지

류마티스 관절염 환자의 항산화 영양소 섭취상태와 생활습관

Antioxidant Nutrient Intakes and Health Behaviors of Rheumatoid Arthritic Patients

  • 이주희 (성신여자대학교 식품영양학과) ;
  • 정은정 (강남대학교 교양학부) ;
  • 이영호 (고려대학교 의과대학 류마티스내과) ;
  • 지종대 (고려대학교 의과대학 류마티스내과) ;
  • 안홍석 (성신여자대학교 식품영양학과)
  • Lee, Ju-Hee (Department of Food & Nutrition, Sungshin Women's University) ;
  • Chung, Eun-Jung (General Education, Kangnam University) ;
  • Lee, Young-Ho (Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, College of Medicine, Korea University) ;
  • Ji, Jong-Dae (Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, College of Medicine, Korea University) ;
  • Ahn, Hong-Seok (Department of Food & Nutrition, Sungshin Women's University)
  • 발행 : 2008.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Previous studies have indicated that incidence of rheumatoid arthritis (RA) is partly related to the damage of antioxidant systems, but etiology of RA is not fully identified. This study was performed to evaluate nutrient intakes including antioxidants, health related behaviors and food habits of RA patients and controls. RA patient group (n = 68) and sex-matched healthy controls (n = 68) were joined in this study. Nutrient intake was estimated using a semiquantitative food frequency questionnaire. As mean age of RA ($52.9{\pm}13.8$ years) was significantly higher than those of controls ($48.7{\mp}5.9$ years), data were analyzed by using Student's t-test, adjusted for age. There was no significant difference between two groups in body mass index. Compared with those of controls, frequencies of drinking (p < 0.001) and coffee consumption (p < 0.05) of RA groups were lower. RA groups had lower frequencies of fruit (p < 0.01), vegetable (p < 0.05) and fatty meat (p < 0.05) consumptions and balanced diet (p < 0.01), and higher frequencies of fried dishes (p < 0.01), and salty dishes (p < 0.01), compared to controls. The most nutrient intakes including energy intake of RA were tended to be lower than those of controls. Vitamin A, ${\beta}$-carotene and vitamin C intakes were significantly lower in RA than controls (p < 0.001). Daily vitamin A, ${\beta}$-carotene and vitamin C intakes of RA were lower than those of control (vitamin A: RA $360.6{\pm}252.23{\mu}g$ RE, control $844.5{\pm}426.2{\mu}g$ RE, p < 0.001; ${\beta}$-carotene: RA $1450.9{\pm}1019.0{\mu}g$, control $3968.8{\pm}2248.21{\mu}g$, p < 0.001; vitamin C; RA $40.6{\pm}21.48mg$, control $84.7{\pm}40.29$, p < 0.001) These results suggest sufficient consumption of antioxidant nutrients may prevent and improve RA status.

키워드

참고문헌

  1. Adam PF, Marano, M.A (1994): Current Estimates from the National Health Interview Survey
  2. Babior BM (1978): Oxygen-dependent microbial killing by phagocytes. N Enql Med 298(13): 721-725 https://doi.org/10.1056/NEJM197803302981305
  3. Bae SC, Kim SJ, Sung MK (2003): Inadequate antioxidant nutrient intake and altered plasma antioxidant status of rheumatoid arthritis patients. J Am Coll Nutr 22(4): 311-315 https://doi.org/10.1080/07315724.2003.10719309
  4. Cerhan JR, Saag KG, Merilino LA, Mikuls TR, Criswell LA (2003): Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol 157(4): 345-454 https://doi.org/10.1093/aje/kwf205
  5. Chung SH, Kim HJ, Ki SH, Kim CG, Hwang IS, Choe JY (2005): Combination treatment with leflunomide and methotrexate in patients with rheumatoid arthritis: the efficacy, safety, and predisposing factors for treatment response. Korean J Int Med 69(1): 10-20
  6. Comstock GW, Burke AE, Hoffman SC (1997): Serum concentrations of $\alpha$-tocopherol, b-carotene, and retinal preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosis. Ann Rheum Dis 56: 323 https://doi.org/10.1136/ard.56.5.323
  7. Egan RW, Paxton J, Kuehl FA Jr (1976): Mechanisms irreversible self deactivation of prostaglandin synthetase. J Biol Chem 251: 7329-7335
  8. Gruenwald J, Graubaum HJ, Hansen K, Grube B (2004): Efficacy and tolerability of a combination of Lyprinol and high concentrations of EPA and DHA in inflammatory rheumatoid disorders. Adv Ther 21(3): 197-201 https://doi.org/10.1007/BF02850125
  9. Halliwell B (1982): Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: a cause of chronic inflammatory disease? Cell Biol Int Rep 6(6): 529-542 https://doi.org/10.1016/0309-1651(82)90175-8
  10. Hanninen, Kaartinen K, Rauma AL, Nenonen M, Torronen R, Hallinen AS, Aldercreutz H, Laakso J (2000): Antioxidants in vegan diet and rheumatic disorders. J Toxicology 30(155): 45-53
  11. Hazes JMW, Dijikmans BAC, Vandenbroucke JP, Vries RRP, Cats A (1990): Lifestyle and the risk of rheumatoid arthritis: cigarette smoking and alcohol consumption. Ann Rheum Dis 49: 980-982 https://doi.org/10.1136/ard.49.12.980
  12. Heliovaara M, Aho K, Knekt P, Impivaara O, Reunanen A, Aromaa A (2005): Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis. Ann Rheum 59: 631-635 https://doi.org/10.1136/ard.59.8.631
  13. Jonsson IM, Verdrengh M, Brisslert M, Lindblad S, Bokarewa M, Islander U, Carlsten H, Ohlsson C, Nandakumar KS, Holmdahl R, Tarkowski A (2006): Ethanol prevents development of destructive arthritis. PNAS 104(1): 258-263
  14. Kalson EW, Mandi LA, Aweh GN, Grodstein F (2003): Coffee consumption and risk of rheumatoid arthritis. Arthritis Rheum 48: 3055-3060 https://doi.org/10.1002/art.11306
  15. Karatas F, Ozates I, Canatan H, Halifeoglu I, Karatepe M, Colakt R (2003): Antioxidant status & lipid peroxidation in patients with rheumatoid arthritis. Indian J Med Res 118: 178-181
  16. Kim HS, Lee JH (2004): Rehabilitation therapy of rheumatoid arthritis. J Kyung Hee Univ Med Cent 20(1): 18-23
  17. Kremer MJ (2000): n-3 acid supplements in rheumatoid arthritis. Am J Clin Nutr 71 (suppl): 349s-351s https://doi.org/10.1093/ajcn/71.1.349s
  18. Manfredsdottir VF, Vikingsdottir T, Josson T, Geirsson AJ, Kjartansson O, Heimidottir M, Sigurdardottir SL, Valdimarsson K, Vikingsson A (2006): The effects of tobacco smoking and rheumatoid factor seropositivity on disease activity joint damage in early rheumatoid arthritis. Rheumatology 45: 734-740 https://doi.org/10.1093/rheumatology/kei240
  19. Mattey DL, Hutchinson D, Dawes PT, Nixon NB, Clarke S, Fisher J, Brownfield A, Alldersea J, Fryer AA, Strange RC (2002): Smoking and Disease Severity in rheumatoid arthritis: Association with polymorphism at the glutathione S-transferase M1 locus. Arthritis & Rheum 46(3): 640-646 https://doi.org/10.1002/art.10174
  20. Merry P, Winyard, PG, Morris CJ, Grootveld M, Blake DR (1989): Oxygen free radicals, inflammation and synovitis: the current status. Am Rheum Dis 48: 864-870 https://doi.org/10.1136/ard.48.10.864
  21. Ministry of Health and Welfare (2006): The 3rd National health and nutrition Examination (KNHANES III)-Illness of adults
  22. Nam YS, Han SY, Choi DH, Yoon TK, Cha KY (1998): A case of rheumatoid factor detective in spontaneous abortion patient. J Korean Society Obstsrics Gyenecology 41(5): 1485-1487
  23. Paredes S, Girona J, Hurt-Camejo E, Vallve JC, Olive S, Heras M, Benito P, Masana L (2002): Antioxidant vitamins and lipid peroxidation in patients with Rheumatoid arthritis: association with inflammatory markers. J Rheumatol 29(11): 2271-2277
  24. Pedersen M, Jacobsen S, Klarlund M, Pedersen BV, Alla Wiil, Wohlfahrt J, Frisch M (2006): Environmental risk factors differ between rheumatoid arthritis with and without auto antibodies against cyclic citrullinated peptides. Arthritis Res Ther 8(4): R133 https://doi.org/10.1186/ar2022
  25. Raederstorff D, Pantze M, Bachmann H, Moser U. (1996): Antiinflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. Int Arch Allergy Immunol. 111(3): 284-290 https://doi.org/10.1159/000237379
  26. Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, Dinarello CA, Rosenberg IH (1994): Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 93(6): 2379-86 https://doi.org/10.1172/JCI117244
  27. Shapiro JA, Koepsell TD, Voigt LF, Dugowson CE, Kestin M (1996): Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiol 7(3): 256-63 https://doi.org/10.1097/00001648-199605000-00007
  28. Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L, EIRA study group (2003): Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum 62: 835-841 https://doi.org/10.1136/ard.62.9.835
  29. Taylor CM, Pye OF (1996): Foundation of Nutrition (New York: The Macmillan Company)
  30. The Korean Nutrition Society (2005): Dietary Reference Intakes for Koreans
  31. Venkatraman, Chu WC. (1999): Effects of dietary $\omega$-3 and $\omega$-6 lipids and vitamin E on serum cytokines, lipid mediators and Anti- DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr 18(6): 602-613 https://doi.org/10.1080/07315724.1999.10718895
  32. http://www.hypertension.or.kr/diagnosis/commonform.php?mode= no&url=/diagnosis/nutrition/index.php (National Hypertension Center)
  33. 한국식품공업협회 식품연구소 (1988): 식품섭취 실태조사를 위 한 식품 및 음식의 눈 대중량