The Journal of Korean Physical Therapy
- Volume 20 Issue 1
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- Pages.57-65
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- 2008
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- 1229-0475(pISSN)
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- 2287-156X(eISSN)
The Activation of Stress-induced Heat Shock Protein 27 and the Relationship of Physical Therapy
스트레스-유도 열충격단백질 27(Heat Shock Protein 27)의 활성과 물리치료의 상관성
- Kim, Mi-Sun (Department of Physical Therapy, the Graduate School, Doctoral Course, Yong In University) ;
- Lee, Sung-Ho (Department of Physical Therapy, the Graduate School of Rehabilitation and Health Science, Master Course, Yong In University) ;
- Kim, Il-Hyun (Department of Physical Therapy, the Graduate School of Rehabilitation and Health Science, Master Course, Yong In University) ;
- Hwang, Byong-Yong (Department of Physical Therapy, Yongin University) ;
- Kim, Jung-Hwan (Department of Physical Therapy, Yongin University)
- 김미선 (용인대학교 대학원) ;
- 이성호 (용인대학교 재활보건과학대학원) ;
- 김일현 (용인대학교 재활보건과학대학원) ;
- 황병용 (용인대학교 물리치료학과) ;
- 김중환 (용인대학교 물리치료학과)
- Published : 2008.03.25
Abstract
Purpose: Heat shock proteins (HSPs) are a group of proteins that are activated when cells are exposed to a variety of environmental stresses, such as infection, inflammation, exposure to toxins, starvation, hypoxia, brain injury, or water deprivation. The activation of HSPs by environmental stress plays a key role in signal transduction, including cytoprotection, molecular chaperone, anti-apoptotic effect, and anti-aging effects. However, the precise mechanism for the action of small HSPs, such as HSP27 and mitogen-activated protein kinases (MAPKs: extracellular-regulated protein kinase 1/2 (ERK1/2), p38MAPK, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), is not completely understood, particularly in application of cell stimulators including platelet-derived growth factor (PDGF), angiotensin II (AngII), tumor necrosis factor