대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권3호
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- Pages.778-786
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- 2008
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- 1226-9174(pISSN)
카페인이 HRV에 미치는 영향과 내관 자침의 효과에 대한 예비연구 : 무작위 이중맹검시험
Short Time Effect of Caffeine on Heart Rate Variability and the Effect of Acupuncture at Neiguan (PC6): A Randomized Double Blind Pilot Study
- 정현숙 (우석대학교 한의과대학 한방내과) ;
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양창섭
(우석대학교 한의과대학 한방내과) ;
- 남지성 (우석대학교 한의과대학 한방내과) ;
- 장인수 (우석대학교 한의과대학 한방내과) ;
- 김락형 (우석대학교 한의과대학 한방신경정신과) ;
- 서의석 (우석대학교 한의과대학 한방내과)
- Jeong, Hyeon-Suk (Department of Internal Medicine, College of Korean Medicine, Woosuk University) ;
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Yang, Chang-Sop
(Department of Internal Medicine, College of Korean Medicine, Woosuk University) ;
- Nam, Ji-Sung (Department of Internal Medicine, College of Korean Medicine, Woosuk University) ;
- Jang, In-Soo (Department of Internal Medicine, College of Korean Medicine, Woosuk University) ;
- Kim, Lak-Hyung (Department of Oriental Neuropsychiatry, College of Korean Medicine, Woosuk University) ;
- Seo, Eui-Seok (Department of Internal Medicine, College of Korean Medicine, Woosuk University)
- 발행 : 2008.09.30
초록
Objectives : This study was to investigate the short time effect of caffeine on heart rate variability(HRV) and the effect of Neiguan(PC6) acupuncture stimulation on HRV. Methods : 27 healthy adult volunteers were randomly allocated to two groups: Neiguan group (N=13) or placebo group (N=14). The study was carried out under a randomized double-blinded placebo-controlled trial method. Each group orally received the same tablets with 200 mg caffeine. After 1 hour, acupuncture was applied to the Neiguan(PC6) points for the Neiguan group, and for the placebo group was applied to a non-acupuncture point. Both groups were estimated with HRV 3 times, before and after caffeine ingestion, 20 minutes after acupuncture stimulation. Results : After taking caffeine, pulse rate, mean-HRV, and pNN50(the proportion derived by dividing NN50 by the total number of NN intervals) decreased, SDNN(standard deviation of all normal-to-normal (NN) intervals), RMSSD (the root square of successive differences), TP log, HF(high frequency), and HRV index was increased. There were significant changes to the autonomic nervous system after taking caffeine. There were no significant differences between the two groups after acupuncture at Neiguan. Conclusion : Caffeine could induce general activation of the autonomic nervous system. Neiguan acupuncture stimulation may not have significant influence on the autonomic nervous system.