The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Doche-tang on Colonic Mucosal Ulcer Induced by DSS in Mice

DSS으로 유발된 생쥐의 대장점막손상에 대한 도체탕(導滯湯)의 효과

  • Lee, Ju-Ah (Department of internal Medicine, Oriental Medical Hospital of Semyung University) ;
  • Kong, Kyung-Hwan (Department of internal Medicine, Oriental Medical Hospital of Semyung University)
  • 이주아 (세명대학교 한의과대학부속 충주병원 내과학교실) ;
  • 공경환 (세명대학교 한의과대학부속 충주병원 내과학교실)
  • Published : 2008.09.30
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Abstract

Objectives : This study was carried out to investigate the effects of Doche-tang on colonic mucosal ulcer induced by dextran sulfate sodium(DSS). Method : The group was divided into three. The normal group consisted of mice that were not inflammation-induced. The control group was composed of untreated colitis elicited mice. The sample group was administered Doche-tang after colitis elicitation. The effects on colonic mucosal ulcers were evaluated by the morphological change of colonic mucosa, the anti-oxidant effect, HSP 70, $NF-{\kappa}B$, COX-1, COX-2 and iNOS. Results : In terms of immunohistochemical findings, the distribution of COX-1 in mice treated with Doche-tang noticeably increased more than that in the control group. The distribution of HSP70, $NF-{\kappa}B$, COX-2, iNOS in mioe treated with Doche-tang decreased more than that in the control group. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by transmission electron microscope. Conclusion : According to the results, Doche-tang is practicable treatment for colonic mucosal ulcer.

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