대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권3호
- /
- Pages.684-702
- /
- 2008
- /
- 1226-9174(pISSN)
지백지황환가미(知柏地黃丸加味)가 monocrotaline으로 유발된 흰쥐의 고혈압 병태모델에 미치는 영향
The Effects of Jibeakjihwanghwangami(JJHG) on Monocrotaline-induced Hypertensive Rats
- 김종원 (대전대학교 한의과대학 심계내과학교실) ;
- 안정조 (대전대학교 한의과대학 심계내과학교실) ;
- 조현경 (대전대학교 한의과대학 심계내과학교실) ;
- 유호룡 (대전대학교 한의과대학 심계내과학교실) ;
- 설인찬 (대전대학교 한의과대학 심계내과학교실) ;
- 김윤식 (대전대학교 한의과대학 심계내과학교실)
- Kim, Jong-Won (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
- An, Joung-Jo (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
- Jo, Hyun-Kyung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
- Yoo, Ho-Ryong (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
- Seol, In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
- Kim, Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
- 발행 : 2008.09.30
초록
This experiment was performed to determine the effect of Jibeakjihwanghwangami(JJHG) on hypertension in monocrotaline-induced hypertensive rats. The results obtained were as follows : 1. JJHG showed a safety in cytotoxicity and toxicity of liver. 2. JJHG showed scavenging activity on DPPH free radicals and SOD-like activity. 3. JJHG showed an inhibitory effect on ACE. 4. JJHG significantly decreased blood pressure and pulse in monocrotaline-induced hypertensive rats. 5. JJHG significantly decreased the levels of plasma aldosterone in monocrotaline-induced hypertensive rats. 6. JJHG significantly decreased the levels of potassium in monocrotaline-induced hypertensive rats. 7. JJHG significantly decreased the levels of uric acid. BUN, and creatinine in monocrotaline-induced hypertensive rats. These results suggest that JJHG might be effective in treatment and prevention of hypertension.