The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 29 Issue 4
- /
- Pages.939-949
- /
- 2008
- /
- 1226-9174(pISSN)
A Comparison Study on Effects of Jisildoche-hwan Extract and Misoprostol on Indomethacin-induced Gastric Mucosal Lesions in Mice
Indomethacin으로 유발된 생쥐의 위점막 손상에 대한 지실도체환(枳實導滯丸)과 Misoprostol의 효과 비교 연구
- Lee, Seul-Hee (Dept. of internal Medicine Oriental Hospital of Sangji University) ;
- Baek, Tae-Hyun (Dept. of internal Medicine Oriental Hospital of Sangji University)
- Published : 2008.12.31
Abstract
Objective : This study was carried out to investigate the effects of Jisildochehwan extract on indomethacin-induced gastric mucosal lesions of mice. as compared with misoprostol. Methods : Experimental mice were classified into four groups. No gastro-inflammation elicited mice were the normal group(NOR). Gastro-inflammation elicited mice were the control group (CON). Misoprostol-administered mice after gastro-inflammation elicitation were the misoprostol-administered group (MA). Jisildochehwan-administered mice after gastro-inflammation elicitation were the Jisildochehwan-administered group(JA). In this study, we examined superoxide dismutase(SOD) ability, anti-inflammatory ability arrangement of mucous-secreted cells. distribution of mucosal neck cells, mucosal surface cells. neutral mucous-secreted cells. PAS reaction. COX-1,