Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antitumor effect of Careya arborea against Ehrlich ascites carcinoma with reference to lipid peroxidation and enzymatic and non enzymatic antioxidant system in Swiss albino mice

  • Kumar, R Sambath (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Sivakumar, T (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Senthil, V (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Murthy, N Venkateswara (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Balasubramaniam, V (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Sabi, R Kanaga (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Sundram, R. Shanmuga (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Perumal, P (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J. K. K. Nataraja College of Pharmacy) ;
  • Mazumder, U K (Division of Pharmacology and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Gupta, M (Division of Pharmacology and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University)
  • Published : 2008.06.30
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Abstract

The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family- Myrtaceae) was evaluated for antitumor activity and antioxidant status against Ehrlich's Ascites Carcinoma (EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered at the doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18 h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor, life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameters were estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cell volume and viable cell count and prolonged the life span of EAC tumor bearing mice. Hematological profiles reverted to more or less normal levels in extract treated mice. The MECA also produced protective effect by decreasing the activity of serum enzymes, bilirubin and increase the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels of lipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content, vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECA exhibited significant antitumor and antioxidant activity in EAC bearing mice.

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