Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

A Comparative study of Warm needling and Bee Venom Pharmacopuncture on Osteoarthritis of the Knee - a Randomized Controlled Trial -

퇴행성슬관절염에 대한 봉약침과 온침효과 비교

  • Yang, Ka-Ram (Department of acupuncture & Moxibustion, College of Oriental Medicine, Kyungwon University) ;
  • Song, Ho-Sueb (Department of acupuncture & Moxibustion, College of Oriental Medicine, Kyungwon University)
  • 양가람 (경원대학교 한의과대학 침구학교실) ;
  • 송호섭 (경원대학교 한의과대학 침구학교실)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective This study was performed to investigate whether Bee Venom Pharmacopuncture(BVP) could be a more effective modality than Warm Needling(WN) in relieving pain and symptoms of knee osteoarthritis(OA). Design Prospective, randomized and controlled clinical trial. Setting Single center trial in Korea Patients 49 volunteers with knee OA participated in the study. All the participants were screened through an inclusion and exclusion criteria. 33 participants were completed the clinical trial. Intervention The subjects were randomly assigned to one of two groups. One group received BVP(n=18), while the other group received WN(n=15). Sixteen sessions of BVP or WN were given at the pain region of the problematic knee for 8 weeks. Primary outcome measure is the Korean translation of Western Ontario and McMaster Universities Osteoarthritis Index scores(Korean WOMAC, KWOMAC). Secondary outcome measure is the physical health scores based on the 36-Item Short-Form Health Survey(SF-36) and Patient Global Assessment(PGA). KWOMAC and SF-36 were measured third (baseline, 4 and 8 weeks). PGA was measured twice(4 and 8 weeks). Results BVP group showed significant decrease compared to WN group in pain, function and total scores of KWOMAC according to the Mann-Whitney U-test. In the PGA, BVP group, compared to WN group, showed a significant increase. Conclusions BVP was more effective in relieving pain of knee OA than WN. These findings suggest that BVP is a promising alternative for treating knee OA.

Keywords

References

  1. Felson DT, Lawrence RC, Hochberg MC, et al. Osteoarthritis: new insights. Part 2: treatment approaches. Ann Intern Med. 2000;133(9):726-37 https://doi.org/10.7326/0003-4819-133-9-200011070-00015
  2. World Health Organization. International Standard Terminologies on Traditional Medicine in the Western Pacific Region. 2007
  3. Hider, R.C. Honeybee venom: a rich source for pharmacologically active peptides. Endeavour 1988;12(2),60-65 https://doi.org/10.1016/0160-9327(88)90082-8
  4. Dong Ju Son et al., Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacology & Therapeutics 2007;115:246-270 https://doi.org/10.1016/j.pharmthera.2007.04.004
  5. Wang Zhizhong. Zhenjiuzishengjing(鍼灸資生經) Classic of Nourishing Life with Acupuncture and Moxibustion. Seoul: Iljungsa. 1991
  6. Moxibustion and meridian of oriental medical laboratory, college of the whole University. Acupuncture & Moxibustion. Seoul: Jipmoondang. 2000:1048-9, 1335-8
  7. Yoo SI, Ahn CB. The modern clinical acupuncture & moxibustion. Seoul: Euisungdang. 2000:707-709
  8. Li CD, Huang XY, Yang XG, et al. Observation on therapeutic effect of warming needle moxibustion on knee osteoarthritis of deficiencycold type. Zhongguo Zhen Jiu. 2006:26(3):189-191
  9. Chen N. Observation on the therapeutic effects of bird-pecking needing and needle warming on bulging of lumbar intervertebral disc. Zhongguo Zhen Jiu. 2006:26(3):213-214
  10. He XW, Huang JH, Zeng LY. Observation on the therapeutic effect of warming needle moxibustion on prolapse of lumbar intervertebral disc. Zhongguo Zhen Jiu. 2007:27(4):264-266
  11. Chen MR, Wang P, Cheng G, et al. Effect of warming needle moxibustion on pain threshold in the patient of sciatica. Zhongguo Zhen Jiu. 2005:25(12):831-833
  12. Xu FQ, Li HX, Huang T. Observation on therapeutic effect of warming needle moxibustion combined with medicine on 128 cases of myasthenia gravis. Zhongguo Zhen Jiu. 2006:26(5):339-341
  13. Berman BM, Lao L, Langenberg P, et al. Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial. Ann Intern Med. 2004;141:901-910
  14. Berman BM, Singh BB, Lao L, et al. A randomized trial of acupuncture as an adjunctive therapy in osteoarthritis of the knee. Rheumatology. 1999;38:346-354 https://doi.org/10.1093/rheumatology/38.4.346
  15. Brinkhaus B, Witt CM, Jena S, et al. Physician and treatment characteristics in a randomized multicentre trial of acupuncture in patients with osteoarthritis of the knee. Complementary Therapies in Medicine. 2007:15:180-189 https://doi.org/10.1016/j.ctim.2006.04.003
  16. Thomas M, Eriksson SV, Lundeberg T. A comparative study of diazepam and acupuncture in patients with osteoarthritis pain: a placebo controlled study. Am J Chin Med. 1991;19:95-100 https://doi.org/10.1142/S0192415X91000156
  17. Ezzo J, Hadhazy V, Birch S. Acupuncture for osteoarthritis of the knee: a systematic review. Arthritis Rheum. 2001;44(4):819-825 https://doi.org/10.1002/1529-0131(200104)44:4<819::AID-ANR138>3.0.CO;2-P
  18. Bae SC, Lee HS, Yun HR, et al. Cross-cultural adaptation and validation of Korean Western Ontarioand McMaster Universities(WOMAC) and Lequesne osteoarthritis indices for clinical research. Osteoarthritis Cartilage. 2001;9:746-750 https://doi.org/10.1053/joca.2001.0471
  19. Kwon, Y. B., Lee, H. J., Han, H. J., Mar, W. C., Kang, S. K., Yoon, O. B., et al. The water-soluble fraction of bee venom produces anti-nociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. Life Sci 2002;71(2): 191-204 https://doi.org/10.1016/S0024-3205(02)01617-X
  20. Kwon, Y. B., Lee, J. D., Lee, H. J., Han, H. J., Mar, W. C., Kang, S. K., et al. Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain 2001;90(3):271-280 https://doi.org/10.1016/S0304-3959(00)00412-7
  21. Doh,W. S., Jang, J. H., Kim, K. H., Yoon, J.W., & Kim, K. S. Effects of bee venom therapy on inflammatory edema on knees of rats. J Kor Acu Mox Soc (1995);12(1):211-220
  22. Lee, S. D., & Kim, K. S. Effects of Achyranthes japonica and bee venom acupuncture on the cell immunity of LPS-induced arthritis in rats. J Kor Acu Mox Soc (1999);6(3):287-316
  23. Yim, Y. K., Seo, J. C., Kim, Y. S., Kim, C. H., Lee, Y. H., & Choi, D. Y. The effect of bee venom acupuncture into Chok-samni(ST36) formalininduced pain behavior. J Kor Acu Mox Soc 2000;17(2):139-152
  24. Do, W. S., Kim, K. H., & Kim, K. S. Effects of aqua-acupuncture(Cortex pumilae, Ramulus cinnamomum, Radix achyranthis, Apitoxin, Calculus bovis, Fel ursi, Moschus compound) in mice with lipopolysaccharide. J Kor Acu Mox Soc 2001;18(1):157-169
  25. Lee, J. H., Kwon, Y. B., Han, H. J., Mar, W. C., Lee, H. J., Yang, I. S., et al. Bee venom pretreatment has both an anti-nociceptive and antiinflammatory effect on carrageenaninduced inflammation. J Vet Med Sci 2001;63(3), 251-259 https://doi.org/10.1292/jvms.63.251
  26. Choi, D. Y., Lee, J. D., & Kim, T. W. The effect of bee venom on type 2 collageninduced arthritis. J Kor Acu Mox Soc 2002;19(2): 92-104
  27. Kim, M. J., Park, S. D., Lee, A. R., Kim, K. H., Jang, J. H., & Kim, K. S. The effect of bee venom acupuncture on protease activity and free radical damage in synovial fluid from collagen-induced arthritis in rats. J Kor Acu Mox Soc 2002;19(5):161-175
  28. Kim, H. W., Kwon, Y. B., Ham, T. B., Roh, D. H., Yoon, S. Y., Lee, H. J., et al. Acupoint stimulation using bee venom attenuates formalin-induced pain behavior and spinal cord fos expression in rats. J Vet Med Sci 2003;65(3):349-355 https://doi.org/10.1292/jvms.65.349
  29. Seo, D. M., Park, D. S., & Kang, S. G. The analgesic effect of bee venom aqua-acupuncture and its mechanism in the rat model with adjuvant-induced arthritis. J Kor Acu Mox Soc 2003;20(2):85-97
  30. Witt C, Brinkhaus B, Jena S, et al. Acupuncture in patients with osteoarthritis of the knee: a randomized trial. Lancet. 2005;366:136-143 https://doi.org/10.1016/S0140-6736(05)66871-7
  31. Singh BB, Berman BM, Hadhazy V, et al. Clinical decisions in the use of acupuncture as an adjunctive therapy for osteoarthritis of the knee. 2001;7:58-65
  32. Manheimer E, Lim BM, Lao L, et al. Acupuncture for osteoarthritis-a randomized trial using a novel sham. Acupuncture in Medicine. 2006:24:7-14 https://doi.org/10.1136/aim.24.Suppl.7
  33. Vas J, Mendez C, Perea-Milla E, et al. Acupuncture as a complementary therapy to the pharmacological treatment of osteoarthritis of the knee: randomized controlled trial. BMJ. 2004;329:12-16 https://doi.org/10.1136/bmj.38238.601447.3A
  34. Scharf HP, Mansmann U, Streitberger K, et al. Acupuncture and knee osteoarthritis: a threearmed randomized trial. Ann Intern Med. 2006;145:12-20 https://doi.org/10.7326/0003-4819-145-1-200607040-00005
  35. Foster NE, Thomas E, Barlas P, et al. Acupuncture as an adjunct to exercise based physiotherapy for osteoarthritis of the knee: randomized controlled rial. BMJ. 2007:335(7617):436 https://doi.org/10.1136/bmj.39280.509803.BE

Cited by

  1. Analgesic Effects of Pharmacopuncture at Taegye(KI3) Acupoint on Formalin-induced Pain vol.33, pp.1, 2016, https://doi.org/10.13045/acupunct.2016004
  2. Trend Analysis of the Research on Bee Venom Acupuncture in South Korea, Based on Published Articles vol.36, pp.4, 2015, https://doi.org/10.13048/jkm.15036