Journal of Applied Biological Chemistry

  • 제51권1호
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  • Pages.7-12
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  • 2008
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  • 1976-0442(pISSN)
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  • 2234-7941(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
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Citrus Peel Wastes as Functional Materials for Cosmeceuticals

  • Kim, Sang-Suk (Department of Chemistry, Cheju National University) ;
  • Lee, Jung-A (Laboratory of Bioresources, Jeju Biodiversity Research Institute (JBRI), Jeju Hi-Tech Industry Development Institute (HiDI)) ;
  • Kim, Ji-Young (Laboratory of Bioresources, Jeju Biodiversity Research Institute (JBRI), Jeju Hi-Tech Industry Development Institute (HiDI)) ;
  • Lee, Nam-Ho (Department of Chemistry, Cheju National University) ;
  • Hyun, Chang-Gu (Laboratory of Bioresources, Jeju Biodiversity Research Institute (JBRI), Jeju Hi-Tech Industry Development Institute (HiDI))
  • 발행 : 2008.02.29
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초록

The suitability of CPWs, by-products of the juice industry, was investigated as a source for the production of cosmeceuticals. Four kinds of CPWs, CW, CWE, CWER, and CWEA, were examined for their antioxidant potentials in terms of DPPH radical-scavenging ability for anti-wrinkle applications, inhibition of tyrosinase or melanin production for whitening products, and anti-inflammatory effects to treat various skin diseases such as atopic dermatitis and acne as well as for anti-bacterial activity against acne-inducing pathogens. Of the four extracts, CWER was the most potent tyrosinase inhibitor ($IC_{50}$ value: $109\;{\mu}g/mL$), and CWEA ($IC_{50}:\;167\;{\mu}g/mL$) showed good antioxidative effects. CWE and CWEA samples had dose-dependent inhibitory effects on the melanin production. The cytotoxic effects of the four CPWs were determined by colorimetric MTT assays using human keratinocyte HaCaT cells. Most extracts exhibited low cytotoxicity at $100\;{\mu}g/mL$. These results suggest CPWs are attractive candidates for topical applications on the human skin.

키워드

참고문헌

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피인용 문헌

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  2. New Trends in Cosmetics: By-Products of Plant Origin and Their Potential Use as Cosmetic Active Ingredients vol.2, pp.2, 2015, https://doi.org/10.3390/cosmetics2020082
  3. Phytochemical, antioxidant, and antibacterial activities of fermented Citrus unshiu byproduct vol.26, pp.2, 2017, https://doi.org/10.1007/s10068-017-0063-9
  4. Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma vol.3, pp.8, 2013, https://doi.org/10.1016/S2221-1691(13)60125-2
  5. Effect of Palmitoleic Acid on Melanogenic Protein Expression in Murine B16 Melanoma vol.59, pp.6, 2008, https://doi.org/10.5650/jos.59.315